Development of an analytical method to determine methyl alcohol and isopropyl alcohol in food using static headspace gas chromatography

Heung Youl Lim; Mi-Hyun Ka; Nae In Chang; Yong Yeon Kim; Han-Seung Shin

doi:10.1007/s10068-023-01356-4

Development of an analytical method to determine methyl alcohol and isopropyl alcohol in food using static headspace gas chromatography

Food Sci Biotechnol. 2023 Jul 17;33(2):389-397. doi: 10.1007/s10068-023-01356-4. eCollection 2024 Jan.

Authors

Heung Youl Lim¹, Mi-Hyun Ka¹, Nae In Chang¹, Yong Yeon Kim², Han-Seung Shin^{2

3}

Affiliations

¹ Korea Health Supplements Association Sub. Korea Health Supplements Institute, Gyeonggi-do, Seongnam-si, 13488 South Korea.
² Department of Food Science and Biotechnology, Dongguk University, Goyang, Kyunggido 410-820 South Korea.
³ Food and Bio Safety Research Center, Dongguk University-Seoul, Goyang-si, Gyeonggi-do, Republic of Korea.

PMID: 38222919
PMCID: PMC10786759 (available on 2024-07-17)
DOI: 10.1007/s10068-023-01356-4

Abstract

A method to determine methanol (MeOH) and isopropyl alcohol (IPA) was developed using static headspace sampling (HSS) with gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). The optimized HSS-GC and HSS-GC/MS methods were validated according to the parameters. The limit of quantification (LOQ) values for MeOH analyzed by HSS-GC/MS and HSS-GC were 0.50-0.56 and 1.97 mg/L, and the corresponding values for IPA were 0.14-0.21 and 1.51 mg/L, respectively. Recoveries were determined by spiking sample matrices, such as vinegar and tea. MeOH and IPA showed excellent recoveries of 93.80-107.60% and 93.92-104.32% with corresponding precisions of 0.51-7.38% and 0.90-7.70%, respectively. Compared to solid-phase microextraction-GC/MS and HSS-GC, the HSS-GC/MS method showed outstanding values for limit of detection and LOQ with improved precision and accuracy. This HSS-GC/MS method was successfully used to monitor residual solvents in 100 food and functional food products.

Keywords: Food; Headspace; Isopropyl alcohol; Methanol; Residual solvent.

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