Impact of probiotic Veillonella atypica FB0054 supplementation on anaerobic capacity and lactate

Kristen Gross; Marina Santiago; Joesi M Krieger; Anthony M Hagele; Kinga Zielinska; Jonathan Scheiman; Ralf Jäger; Alex Kostic; Chad M Kerksick

doi:10.1016/j.isci.2023.108643

Impact of probiotic Veillonella atypica FB0054 supplementation on anaerobic capacity and lactate

iScience. 2023 Dec 8;27(1):108643. doi: 10.1016/j.isci.2023.108643. eCollection 2024 Jan 19.

Authors

Kristen Gross¹, Marina Santiago², Joesi M Krieger¹, Anthony M Hagele¹, Kinga Zielinska^{2

3}, Jonathan Scheiman², Ralf Jäger⁴, Alex Kostic^{2

5

6}, Chad M Kerksick¹

Affiliations

¹ Exercise and Performance Nutrition Laboratory, Kinesiology Department, College of Science, Technology, and Health, Lindenwood University, St. Charles, MO, USA.
² FitBiomics, Inc, New York City, NY, USA.
³ Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.
⁴ Increnovo, LLC, Whitefish Bay, WI, USA.
⁵ Department of Microbiology, Harvard Medical School, Boston, MA, USA.
⁶ Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA.

Abstract

Seven healthy, physically active men (n = 3) and women (n = 4) (30.7 ± 7.5 years, 172.7 ± 8.7 cm, 70.4 ± 11.6 kg, 23.6 ± 4.1 kg/m², 49.2 ± 8.4 mL/kg/min) supplemented for 14 days with a placebo (PLA) or 1 × 10¹⁰ CFU doses of the probiotic Veillonella atypica FB0054 (FitBiomics, New York, NY). Participants had safety panels, hemodynamics, lactate, and anaerobic capacity assessed. Stool samples were collected to evaluate for metagenomic and metabolomic changes. Exhaustion times were not different between groups, whereas anaerobic capacity tended to shorten with PLA (61.14 ± 72.04 s; 95% CI: -5.49, 127.77 s, p = 0.066) with no change with VA (13.29 ± 100.13 s, 95% CI: -79.32, 105.89 s, p = 0.738). No changes in lactate, hemodynamics, or bacterial community changes were observed, whereas 14 metabolites exhibited differential expression patterns with VA supplementation. In conclusion, VA maintained exercise performance that tended to decline in PLA. Supplementation was well tolerated with no changes in safety markers or reported adverse events.

Keywords: Health sciences; Medicine; Microbiome; Natural sciences.