Comparison of results and age-related changes in establishing reference intervals for CEA, AFP, CA125, and CA199 using four indirect methods

Juping Chen; Lina Fan; Zheng Yang; Dagan Yang

doi:10.1016/j.plabm.2023.e00353

Comparison of results and age-related changes in establishing reference intervals for CEA, AFP, CA125, and CA199 using four indirect methods

Pract Lab Med. 2023 Dec 27:38:e00353. doi: 10.1016/j.plabm.2023.e00353. eCollection 2024 Jan.

Authors

Juping Chen^{1

2}, Lina Fan³, Zheng Yang³, Dagan Yang³

Affiliations

¹ Department of Laboratory Medicine, Liangzhu Branch of the First Affiliated Hospital of Zhejiang University, Zhejiang, China.
² School of Public Health, Zhejiang University School of Medicine, Zhejiang, China.
³ Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China.

Abstract

•The reference intervals calculated using RefineR, Kosmic, TMC, and non-parametric methods are similar.•TMC algorithm is more robust, demonstrates a high pass rate among the four methods and has the ability to automatically isolate outliers.•The reference intervals of CA125 and CA199 showed significant differences between age and sex.