Model for Interpreting Discordant SARS-CoV-2 Diagnostic Test Results

Emerg Infect Dis. 2024 Feb;30(2):388-391. doi: 10.3201/eid3002.230200. Epub 2024 Jan 12.

Abstract

We devised a model to interpret discordant SARS-CoV-2 test results. We estimate that, during March 2020-May 2022, a patient in the United States who received a positive rapid antigen test result followed by a negative nucleic acid test result had only a 15.4% (95% CI 0.6%-56.7%) chance of being infected.

Keywords: COVID-19; PCR; SARS; SARS-CoV-2; coronavirus; coronavirus disease; diagnostic test; rapid antigen test; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.

MeSH terms

  • COVID-19 Testing
  • COVID-19* / diagnosis
  • Diagnostic Tests, Routine
  • Humans
  • SARS-CoV-2*
  • Sensitivity and Specificity
  • United States / epidemiology