Large area fractional laser treatment of mouse skin increases energy expenditure

Nunciada Salma; Michael Wang-Evers; Daniel Karasik; Armen Yerevanian; Heather Downs; Tuanlian Luo; Abigail E Doyle; Zeina Tannous; Jose M Cacicedo; Dieter Manstein

doi:10.1016/j.isci.2023.108677

Large area fractional laser treatment of mouse skin increases energy expenditure

iScience. 2023 Dec 7;27(1):108677. doi: 10.1016/j.isci.2023.108677. eCollection 2024 Jan 19.

Authors

Affiliations

¹ Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, MA 02129, USA.
² Technion - Israel Institute of Technology, Ruth and Bruce Rappaport Faculty of Medicine, Haifa, Israel.
³ Department of Medicine, Diabetes Unit, Endocrine Division, and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
⁴ Department of Dermatology, School of Medicine, Lebanese American University, Beirut, Lebanon.
⁵ Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
⁶ Department of Research and Development ALPCO Diagnostics, Salem, NH, USA.

Abstract

Fractional laser (FL) treatment is a common dermatologic procedure that generates arrays of microscopic treatment zones separated by intact tissue, promoting fast wound healing. Using a mouse model, we introduced a large area fractional laser treatment (LAFLT) method to study metabolic effects. Using two laser modalities, ablative FL (AFL) and non-ablative FL (NAFL), and exposing different percentages of mice's total body surface area (TBSA), we followed changes in metabolic parameters in real time using metabolic cages. Additionally, body composition, markers of inflammation, neurohormonal signaling, and browning of adipocytes were investigated. LAFLT, especially in high TBSA groups, had specific metabolic effects such as significantly increased average daily energy expenditure, increased fat mass loss, systemic browning of adipocytes, and inflammatory states, without compromising other organs. The ability of LAFLT to stimulate metabolism in a controlled way could develop into a promising therapeutic treatment to induce positive metabolic changes that replace or augment systemic drugs.

Keywords: Biological sciences; Dermatology; Immunology; Photomedicine.

Abstract

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