Navigating the B vitamins: Dietary diversity, microbial synthesis, and human health

Yudie Yang; Yize Ke; Xinyan Liu; Zhidong Zhang; Rongji Zhang; Fang Tian; Luqian Zhi; Guoping Zhao; Bomin Lv; Sha Hua; Hao Wu

doi:10.1016/j.chom.2023.12.004

Navigating the B vitamins: Dietary diversity, microbial synthesis, and human health

Cell Host Microbe. 2024 Jan 10;32(1):12-18. doi: 10.1016/j.chom.2023.12.004.

Authors

Yudie Yang¹, Yize Ke¹, Xinyan Liu¹, Zhidong Zhang², Rongji Zhang², Fang Tian³, Luqian Zhi¹, Guoping Zhao¹, Bomin Lv⁴, Sha Hua⁵, Hao Wu⁶

Affiliations

¹ State Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200433, China.
² State Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200433, China; College of Life Sciences, Inner Mongolia University, Hohhot 010070, China.
³ Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
⁴ State Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200433, China. Electronic address: bominlv@fudan.edu.cn.
⁵ Department of Cardiovascular Medicine, Heart Failure Center, Ruijin Hospital Lu Wan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: shahua@shsmu.edu.cn.
⁶ State Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200433, China; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: hao_w@fudan.edu.cn.

PMID: 38211561
DOI: 10.1016/j.chom.2023.12.004

Abstract

B vitamins are intricately involved in various physiological processes vital for health. Their significance is complicated by the heterogeneous landscape of B vitamin distribution in diets and the contributions of the gut microbiota. Here, we delve into the impact of these factors on B vitamins and introduce strategies, with a focus on microbiota-based therapeutic options, to enhance their availability for improved well-being. Additionally, we provide an ecological and evolutionary perspective on the importance of B vitamins to human-microbiota interactions. In the dynamic realms of nutrition and microbiome science, these essential micronutrients continue to play a fundamental role in our understanding of disease development.

Keywords: B vitamins; diet; gut microbiota; metabolic diseases.

MeSH terms

Diet
Gastrointestinal Microbiome* / physiology
Humans
Microbiota* / physiology
Nutritional Status
Vitamin B Complex*

Substances

Vitamin B Complex