Do survivors of borderline ovarian tumors have susceptibility to secondary primary malignancies? A SEER population-based study

Abstract

Objective: To describe the risk of women who have survived borderline ovarian tumors (BOT) developing second primary malignancies (SPM).

Methods: This work employed the Surveillance, Epidemiology, and End Results (SEER) Program to conduct a retrospective study of patients diagnosed with BOT. The SEER stat software was used to calculate the standardized incidence ratio (SIR). Cases with pathologic diagnosis and for which information on prognostic factors were available were obtained and analyzed using the Fine and Gray model, with non-SPM death as a competing event.

Results: The risk of developing SPM among BOT survivors was not elevated compared with that expected in the general population (SIR 0.88, 95% confidence interval [CI] 0.80-0.96) between 1975 and 2017. Of 3661 patients with BOT diagnosed between 1977 and 2000, 477 patients (13.03%) experienced the development of SPM during the median follow up of 19.43 years and the cumulative incidence of SPM over a span of 25 years was 15.52%. Patients with mucinous BOT (P = 0.028), age older than 50 years (P < 0.001), or no lymph node dissection (P = 0.042), had a higher cumulative incidence of SPM in univariate analysis. In the multivariable competing risk analysis, performing lymphadenectomy (subdistribution hazard ratios [sdHR] 0.79, 95% CI 0.64-0.98), age (sdHR 1.03, 95% CI 1.02-1.03) could strongly predict the risk of SPM.

Conclusion: In contrast to ovarian cancer, women with BOT were not more prone to develop SPM.

Keywords: borderline ovarian tumors; competing risk mode; cumulative incidence function; second primary malignancies; standardized incidence ratio; surveillance epidemiology and end results (SEER).