Synthesis, Structure, Biological Activity, and Luminescence Properties of a "Butterfly"-Type Silver Cluster with 3-Benzyl-4-phenyl-1,2,4-triazol-5-thiol

Dmitriy S Yambulatov; Irina A Lutsenko; Dmitry E Baravikov; Fedor M Dolgushin; Tatiana V Astaf'eva; Olga B Bekker; Lusik G Nersisyan; Melanya A Samvelyan; Tariel V Ghochikyan; Mikhail A Kiskin; Igor L Eremenko; Vladimir K Ivanov

doi:10.3390/molecules29010105

Synthesis, Structure, Biological Activity, and Luminescence Properties of a "Butterfly"-Type Silver Cluster with 3-Benzyl-4-phenyl-1,2,4-triazol-5-thiol

Molecules. 2023 Dec 23;29(1):105. doi: 10.3390/molecules29010105.

Affiliations

¹ Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky Prosp., 119991 Moscow, Russia.
² Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina, 3, 119333 Moscow, Russia.
³ Faculty of Chemistry, Yerevan State University, 1 A Manoukyan Str., Yerevan 0025, Armenia.

Abstract

A new silver(I) cluster [Ag₈L₄(Py)(Pype)]·4Py·11H₂O (I) with 3-benzyl-4-phenyl-1,2,4-triazol-5-thiol (L) was synthesized via the direct reaction of AgNO₃ and L in MeOH, followed by recrystallization from a pyridine-piperidine mixture. The compound I was isolated in a monocrystal form and its crystal structure was determined via single crystal X-ray diffraction. The complex forms a "butterfly" cluster with triazol-5-thioles. The purity of the silver complex and its stability in the solution was confirmed via NMR analysis. Excitation and emission of the free ligand and its silver complex were studied at room temperature for solid samples. The in vitro biological activity of the free ligand and its complex was studied in relation to the non-pathogenic Mycolicibacterium smegmatis strain. Complexation of the free ligand with silver increases the biological activity of the former by almost twenty times. For the newly obtained silver cluster, a bactericidal effect was established.

Keywords: 1,2,4-triazole; biological activity; luminescence; metallodrugs; molecular structure; silver; single crystal.

MeSH terms

Anti-Bacterial Agents / pharmacology
Ligands
Luminescence*
Silver* / pharmacology
Sulfhydryl Compounds

Substances

Silver
Ligands
Anti-Bacterial Agents
Sulfhydryl Compounds

Grants and funding

The work was supported by the Ministry of Science and Higher Education of Russia as part of the state assignment of Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences.