N,N-Dimethyl Formamide European Restriction Demands Solvent Substitution in Research and Development

James Sherwood; Fernando Albericio; Beatriz G de la Torre

doi:10.1002/cssc.202301639

N,N-Dimethyl Formamide European Restriction Demands Solvent Substitution in Research and Development

ChemSusChem. 2024 Apr 22;17(8):e202301639. doi: 10.1002/cssc.202301639. Epub 2024 Jan 10.

Authors

James Sherwood¹, Fernando Albericio², Beatriz G de la Torre³

Affiliations

¹ Green Chemistry Centre of Excellence, Department of Chemistry, University of York, Heslington, North Yorkshire, UK., YO10 5DD.
² School of Chemistry and Physics, University of KwaZulu-Natal, Durban, 4000, South Africa.
³ School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa.

PMID: 38200662
DOI: 10.1002/cssc.202301639

Abstract

As of December 2023, the use of common solvent N,N-dimethyl formamide (DMF) will be restricted in the European Union because of its reproductive health hazard. Industrial facilities must comply with stricter exposure limits, and researchers are recommended to find alternative solvents. Here we explain the restrictions on DMF, which disciplines are affected, and how to substitute DMF to keep research and development commercially relevant.

Keywords: DMF; N,N-Dimethyl formamide; REACH; solvent; substitution.

Publication types

Review

MeSH terms

Dimethylformamide* / chemistry
European Union
Humans
Research
Solvents* / chemistry

Substances

Dimethylformamide
Solvents