Endometrioid type adenocarcinoma in situ as a potential precursor lesion for extremely rare invasive endometrioid type adenocarcinoma of the cervix

Gian Franco Zannoni; Angela Santoro; Francesca Addante; Federica Cianfrini; Simona Stolnicu

doi:10.1016/j.prp.2023.155062

Endometrioid type adenocarcinoma in situ as a potential precursor lesion for extremely rare invasive endometrioid type adenocarcinoma of the cervix

Pathol Res Pract. 2024 Feb:254:155062. doi: 10.1016/j.prp.2023.155062. Epub 2023 Dec 25.

Authors

Gian Franco Zannoni¹, Angela Santoro², Francesca Addante², Federica Cianfrini², Simona Stolnicu³

Affiliations

¹ Operative Unit of General Pathological Anatomy, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: gianfranco.zannoni@unicatt.it.
² Operative Unit of General Pathological Anatomy, Università Cattolica del Sacro Cuore, Rome, Italy.
³ Department of Pathology, University of Medicine Pharmacy, Sciences and Technology of Targu Mures Romania, Romania.

PMID: 38199133
DOI: 10.1016/j.prp.2023.155062

Abstract

HPV-independent in situ adenocarcinomas have been only recently added to the WHO 2020 classification. To date, little information has been published about HPVindependent precursor lesions. In particular, regardiong the extremely rare cervical endometrioid type adenocarcinoma thought to arise in the setting of cervical endometriosis, a premalignant lesion is still not well defined. In this short communication we describe a possible precursor to invasive cervical endometrioid type adenocarcinoma in a 39-yr-old patient, with a previous history of breast cancer.

Keywords: Cervix pathology; Differential diagnosis; New pathological entities.

MeSH terms

Adenocarcinoma in Situ* / pathology
Carcinoma, Endometrioid* / pathology
Cervix Uteri / pathology
Female
Humans
Uterine Cervical Neoplasms* / pathology