Kidney macrophages tap the stream

Pedro H V Saavedra; Justin S A Perry

doi:10.1016/j.immuni.2023.12.008

Kidney macrophages tap the stream

Immunity. 2024 Jan 9;57(1):3-5. doi: 10.1016/j.immuni.2023.12.008.

Authors

Pedro H V Saavedra¹, Justin S A Perry²

Affiliations

¹ Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
² Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College, Cornell University, New York, NY, USA. Electronic address: perryj@mskcc.org.

PMID: 38198853
DOI: 10.1016/j.immuni.2023.12.008

Abstract

Tissue-resident macrophages are essential for maintaining organismal homeostasis, but the precise mechanisms that macrophages use to perform this function are not fully understood. In this issue of Immunity, He et al. demonstrate that renal macrophages surveil and sample urine particles, ensuring optimal collecting duct flow and preventing kidney stone development.

MeSH terms

Homeostasis
Kidney*
Macrophages
Rivers*