A New Twist on a Classic: Enhancing Radioiodine Uptake in Advanced Thyroid Cancer

Clin Cancer Res. 2024 Apr 1;30(7):1220-1222. doi: 10.1158/1078-0432.CCR-23-3503.

Abstract

Advanced differentiated thyroid cancer that is resistant to radioactive iodine therapy may become responsive with a unique treatment combination of chloroquine and vorinostat. This treatment was demonstrated in cellular and animal models of thyroid cancer to inhibit endocytosis of the plasma membrane-bound iodine transporter, NIS, and restore iodine uptake. See related article by Read et al., p. 1352.

MeSH terms

  • Animals
  • Iodine Radioisotopes / metabolism
  • Iodine Radioisotopes / therapeutic use
  • Iodine*
  • Symporters* / genetics
  • Thyroid Neoplasms* / drug therapy
  • Thyroid Neoplasms* / radiotherapy

Substances

  • Iodine Radioisotopes
  • Symporters
  • Iodine