Autoimmune Disease-Related Dry Eye Diseases and Their Placement Under the Revised Classification Systems: An Update

Alara Kılıççıoğlu; Deniz Oncel; Ali Riza Cenk Celebi

doi:10.7759/cureus.50276

Autoimmune Disease-Related Dry Eye Diseases and Their Placement Under the Revised Classification Systems: An Update

Cureus. 2023 Dec 10;15(12):e50276. doi: 10.7759/cureus.50276. eCollection 2023 Dec.

Authors

Alara Kılıççıoğlu^{1

2}, Deniz Oncel³, Ali Riza Cenk Celebi²

Affiliations

¹ Neurology, Szeged University, Szeged, HUN.
² Ophthalmology, Acibadem University, Istanbul, TUR.
³ Ophthalmology, Stritch School of Medicine, Loyola University Chicago, Chicago, USA.

Abstract

Dry eye disease (DED) is a chronic and progressive disorder involving the ocular surface, characterized by disturbances in tear film composition, instability of the tear film, and inflammation of the ocular surface. There are two forms of DED: aqueous-deficient dry eye (ADDE) and evaporative dry eye (EDE). Autoimmune diseases are systemic disorders involving multiple organs, including the eyes, and have a significant impact on DED. There have been multiple studies demonstrating the relation between autoimmune diseases and DED. This article reviews the current knowledge regarding the epidemiological characteristics, pathogenesis, and treatments of autoimmune disease-related DED.

Keywords: autoimmune disease; autoimmune related ded; dry eye disease; keratoconjunctivitis sicca; treatment of ded.

Publication types

Review