Therapeutic efficacy of rare earth carbonate with chemoradiotherapy in late-stage non-small cell lung cancer: a cohort prospective study

Qiang Cao; Xia Ye; Xinyan Wu; Qi Zhang; Junling Gong; Yuquan Chen; Yanwei You; Jun Shen; Yi Qiang; Guangzhu Cao

doi:10.3389/fendo.2023.1301032

Therapeutic efficacy of rare earth carbonate with chemoradiotherapy in late-stage non-small cell lung cancer: a cohort prospective study

Front Endocrinol (Lausanne). 2023 Dec 15:14:1301032. doi: 10.3389/fendo.2023.1301032. eCollection 2023.

Authors

Qiang Cao^#^{1

2}, Xia Ye^#³, Xinyan Wu^#⁴, Qi Zhang^#⁵, Junling Gong^#⁶, Yuquan Chen^#⁷, Yanwei You⁸, Jun Shen², Yi Qiang¹, Guangzhu Cao¹

Affiliations

¹ Department of Earth Sciences, Kunming University of Science and Technology, Kunming, China.
² Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
³ Department of Oncology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
⁴ College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
⁵ Undergraduate Department, Taishan University, Taian, China.
⁶ School of Public Health, Nanchang University, Nanchang, China.
⁷ Institute of Medical Information/Library, Chinese Academy of Medical Sciences, Beijing, China.
⁸ Division of Sports Science & Physical Education, Tsinghua University, Beijing, China.

^# Contributed equally.

Abstract

Objective: To compare the therapeutic effects and adverse reactions of sterilizing rare earth carbonate combined with concurrent chemoradiotherapy and simple concurrent chemoradiotherapy in the treatment of late-stage non-small cell lung cancer (NSCLC), and to analyze the reasons for the differences.

Method: A total of 817 patients with pathologically diagnosed late-stage NSCLC from June 1, 2021 to December 30, 2022, in the affiliated hospital of Kunming University of Science and Technology, were selected. They were randomly divided into a control group of 394 people and an experimental group of 423 people. The control group was given concurrent chemoradiotherapy (cisplatin + etoposide), while the experimental group simultaneously took a low dose of sterilized rare earth carbonate (0.05mg/Kg). The χ² test and Fisher's test were used to compare the clinical pathological features, objective response rate (ORR), ECOG score, and adverse reactions of the two groups of patients, while survival analysis was used to compare the progression-free survival (PFS) of the two groups. Cox regression analysis was used to test factors related to prognosis.

Results: The differences in clinical pathological features between the two groups of patients were not statistically significant, with all P>0.05. The ORR of the control group was 45.18% (178/394), and the experimental group was 89.83% (380/423), with a statistically significant difference (P=0.001). After treatment, the ECOG score of the experimental group was lower than that of the control group, P<0.001. The adverse reaction grading of patients in both groups was below level 3 after treatment, and no treatment-related fatalities occurred. The risk of pulmonary infection and bone marrow suppression in the experimental group was lower than that in the control group.

Conclusion: In late-stage NSCLC patients, compared with simple concurrent chemoradiotherapy, the combination of concurrent chemoradiotherapy and sterilizing rare earth carbonate can significantly improve the short-term therapeutic effect and prognosis of patients, with good safety.

Keywords: concurrent chemoradiotherapy; immune escape; lung cancer; non-small cell lung cancer; prognostic factors; progression-free survival.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbonates
Carcinoma, Non-Small-Cell Lung* / therapy
Chemoradiotherapy
Humans
Lung Neoplasms* / therapy
Metals, Rare Earth*
Prospective Studies

Substances

Carbonates
Metals, Rare Earth

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by National Natural Science Foundation of China (No.42267063).