Novel small-molecule inhibitors of SARS-CoV-2 main protease with nanomolar antiviral potency

Affiliations

• ¹ Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, China.
• ² Institute of Health Inspection and Testing, Hubei Provincial Center for Disease Control and Prevention (Hubei CDC), Wuhan 430079, China.
• ³ Suzhou Ark Biopharmaceutical Co. Ltd., 218 Xinghu Street, Suzhou, Jiangsu 215123, China.
• ⁴ Suzhou Ark Biopharmaceutical Co. Ltd., 218 Xinghu Street, Suzhou, Jiangsu 215123, China. Electronic address: guowei.song@arkbiosciences.com.
• ⁵ Suzhou Ark Biopharmaceutical Co. Ltd., 218 Xinghu Street, Suzhou, Jiangsu 215123, China.
• ⁶ Suzhou Ark Biopharmaceutical Co. Ltd., 218 Xinghu Street, Suzhou, Jiangsu 215123, China.
• ⁷ Institute of Health Inspection and Testing, Hubei Provincial Center for Disease Control and Prevention (Hubei CDC), Wuhan 430079, China. Electronic address: ckreal@163.com.
• ⁸ Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, China; Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: yanli@hust.edu.cn.