Risk factors of diabetes and cancer-specific mortalities in patients with infiltrating ductal carcinoma of the breast: a population-based study

Alaa Ahmed Elshanbary; Mohamed Sayed Zaazouee; Anas Zakarya Nourelden; Mohammed Al-Kafarna; Sajeda Ghassan Matar; Ahmed Saad Elsaeidy; Khaled Mohamed Ragab; Mahmoud M Elhady; Ghadeer M Albadrani; Ahmed E Altyar; Osama A Kensara; Mohamed M Abdel-Daim

doi:10.1097/CEJ.0000000000000869

Risk factors of diabetes and cancer-specific mortalities in patients with infiltrating ductal carcinoma of the breast: a population-based study

Eur J Cancer Prev. 2023 Dec 27. doi: 10.1097/CEJ.0000000000000869. Online ahead of print.

Affiliations

¹ Faculty of Medicine, Alexandria University, Alexandria.
² Faculty of Medicine, Al-Azhar University, Assiut.
³ Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
⁴ Faculty of Pharmacy, Al-Azhar University, Gaza, Palestine.
⁵ Faculty of Pharmacy, University of Jordan, Amman, Jordan.
⁶ Faculty of Medicine, Benha University, Benha.
⁷ Faculty of Medicine, Minia University, Minia, Egypt.
⁸ Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh.
⁹ Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University.
¹⁰ Pharmacy Program, Batterjee Medical College, Jeddah.
¹¹ Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah.
¹² Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, Jeddah, Saudi Arabia.
¹³ Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.

PMID: 38190207
DOI: 10.1097/CEJ.0000000000000869

Abstract

Background and aims: Breast cancer is considered one of the most common neoplasms worldwide. Diabetes (DM) increases mortality among postmenopausal patients with breast cancer. Our study aims to identify the risk factors of DM-specific mortality and infiltrating ductal carcinoma (IDC) mortality in patients with IDC of the breast.

Materials and methods: Data of IDC patients were obtained from the Surveillance, Epidemiology, and End Results database from 1975 to 2016. Independent variables included age, race, marital status, the primary site of IDC, breast subtype, the disease stage, grade, chemotherapy, radiation, and surgery. Kaplan-Meier, Cox and Binary regression tests were used to analyze the data using SPSS software.

Results: A total of 673 533 IDC patients were analyzed. Of them, 4224 died due to DM and 116 822 died due to IDC. Factors that increase the risk of overall, IDC-specific, and DM-specific mortalities include older age, black race, widowed, uninsured, regional and distant stages, grade II and III, and no treatment with chemotherapy or radiotherapy or surgery. Additionally, the IDC mortality increased with separated status, all primary sites, all breast subtypes, and stage IV.

Conclusion: In patients with IDC, controlling DM besides cancer is recommended to reduce the mortality risk. Old, black, widowed, uninsured, regional and distant stages, grade II and III, and no treatment are common risk factors for DM- and IDC-mortality.