Surgical radioguidance with beta-emitting radionuclides; challenges and possibilities: A position paper by the EANM

Pedro Fragoso Costa; Kuangyu Shi; Soren Holm; Sergi Vidal-Sicart; Tereza Kracmerova; Giovanni Tosi; Jan Grimm; Dimitris Visvikis; Wolfram H Knapp; Gopinath Gnanasegaran; Fijs W B van Leeuwen

doi:10.1007/s00259-023-06560-2

Surgical radioguidance with beta-emitting radionuclides; challenges and possibilities: A position paper by the EANM

Eur J Nucl Med Mol Imaging. 2024 Jan 8. doi: 10.1007/s00259-023-06560-2. Online ahead of print.

Authors

Pedro Fragoso Costa¹, Kuangyu Shi^{2

3}, Soren Holm⁴, Sergi Vidal-Sicart⁵, Tereza Kracmerova⁶, Giovanni Tosi⁷, Jan Grimm^{8

9}, Dimitris Visvikis¹⁰, Wolfram H Knapp¹¹, Gopinath Gnanasegaran^{12

13}, Fijs W B van Leeuwen¹⁴

Affiliations

¹ Department of Nuclear Medicine, University Hospital Essen, West German Cancer Center (WTZ), University of Duisburg-Essen, Essen, Germany. pedro.fragoso-costa@uni-due.de.
² Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
³ Computer Aided Medical Procedures and Augmented Reality, Institute of Informatics I16, Technical University of Munich, Munich, Germany.
⁴ Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University Hospital Copenhagen, Copenhagen, Denmark.
⁵ Nuclear Medicine Department, Hospital Clinic Barcelona, Barcelona, Spain.
⁶ Department of Medical Physics, Motol University Hospital, Prague, Czech Republic.
⁷ Department of Medical Physics, Ospedale U. Parini, Aosta, Italy.
⁸ Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
⁹ Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
¹⁰ UMR 1101, LaTIM, INSERM, University of Brest, Brest, France.
¹¹ Department of Nuclear Medicine, Medizinische Hochschule Hannover, Hannover, Germany.
¹² Institute of Nuclear Medicine, University College London Hospital, Tower 5, 235 Euston Road, London, NW1 2BU, UK.
¹³ Royal Free London NHS Foundation Trust Hospital, London, UK.
¹⁴ Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.

PMID: 38189911
DOI: 10.1007/s00259-023-06560-2

Abstract

Radioguidance that makes use of β-emitting radionuclides is gaining in popularity and could have potential to strengthen the range of existing radioguidance techniques. While there is a strong tendency to develop new PET radiotracers, due to favorable imaging characteristics and the success of theranostics research, there are practical challenges that need to be overcome when considering use of β-emitters for surgical radioguidance. In this position paper, the EANM identifies the possibilities and challenges that relate to the successful implementation of β-emitters in surgical guidance, covering aspects related to instrumentation, radiation protection, and modes of implementation.

Keywords: Beta emitting Radionuclides; Image guided surgery; Radiation exposure; Radioguidance; Radiotracers.