Two-sample Mendelian randomization study reveals no causal relationship between inflammatory bowel disease and urological cancers

Haoyang Zhang; Can Hu; Zhiyu Zhang; Peng Li; Gang Shen; Jiale Sun

doi:10.3389/fgene.2023.1275247

Two-sample Mendelian randomization study reveals no causal relationship between inflammatory bowel disease and urological cancers

Front Genet. 2023 Dec 21:14:1275247. doi: 10.3389/fgene.2023.1275247. eCollection 2023.

Authors

Haoyang Zhang^#¹, Can Hu^#², Zhiyu Zhang³, Peng Li¹, Gang Shen¹, Jiale Sun¹

Affiliations

¹ Department of Urology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, Jiangsu, China.
² Department of Urology, Suzhou Xiangcheng People's Hospital, Suzhou, China.
³ Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

^# Contributed equally.

Abstract

Background: The relationship between inflammatory bowel disease (IBD) and urological cancers has been identified in epidemiological and observational studies, while the causality remains uncertain. We examined whether IBD is causally associated with urological cancers in a Mendelian randomization (MR) study. Methods: The causal relationship between IBD, its main subtypes, and urological cancers was investigated using genome-wide association study data. To obtain more reliable conclusions, all outcomes were divided into training and validation sets. Eligible single-nucleotide polymorphisms were selected as instrumental variables based on MR analysis assumptions. The inverse variance-weighted (IVW) method was employed as the main method along with four other complementary methods. Results: In this two-sample MR study, no genetic evidence for the causal effect of IBD on urological cancers was found in either the training or validation sets using the IVW method. Similarly, we did not observe any significant association between Crohn's disease or ulcerative colitis and urological cancers. The results of the other methods are in accordance with those obtained using the IVW method. Conclusion: In this study, we confirmed that IBD is not a causal genetic risk factor for urological cancer in a European population.

Keywords: Mendelian randomization; causality; inflammatory bowel disease; single-nucleotide polymorphisms; urological cancers.

Grants and funding

The authors declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from the Suzhou Industrial Park clinical medical expert team introduction project (0202140004), Jiangsu Industry University Research Cooperation Project (BY2022855), and Open project of the State Key Laboratory of Radiation Medicine and Protection (GZK1202304).