D130A variant on Parkinson 22-related CHCHD2 is predicted to have decreased protein movement

Hanna J Jefcoat; Cynthia L Stenger; Luke Terwilliger; Michele Morris; Olivia Morris

doi:10.17912/micropub.biology.001093

D130A variant on Parkinson 22-related CHCHD2 is predicted to have decreased protein movement

MicroPubl Biol. 2023 Dec 22:2023:10.17912/micropub.biology.001093. doi: 10.17912/micropub.biology.001093. eCollection 2023.

Authors

Hanna J Jefcoat¹, Cynthia L Stenger², Luke Terwilliger³, Michele Morris⁴, Olivia Morris¹

Affiliations

¹ Biology, University of North Alabama, Florence, Alabama, United States.
² Mathematics, University of North Alabama, Florence, Alabama, United States.
³ Computer Science, University of North Alabama, Florence, Alabama, United States.
⁴ HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States.

Abstract

Parkinson's disease is the second most common neurodegenerative disease which is caused by a lack of dopamine in the brain. Parkinson 22 is a form of Parkinson's disease caused by variations in the coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) protein. This study investigates an aspartic acid-to-alanine swap on amino acid position 130 (D130A) of the CHCHD2 protein. We have employed protein modeling, conservation analysis, and molecular dynamics simulations to gain an understanding of the effects of the D130A variant on CHCHD2 protein structure and movement.

Grants and funding

This work is supported by the National Science Foundation under Grant Number 2120918. Any opinions, findings, conclusions, or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation