Serum oxidative stress factors predict myocardial ischemia reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction and type 2 diabetes mellitus

Chunyu Zhao; Tianze Liu; Hong Wei; Jianing Li

doi:10.5114/aic.2023.133475

Serum oxidative stress factors predict myocardial ischemia reperfusion injury after percutaneous coronary intervention in patients with acute myocardial infarction and type 2 diabetes mellitus

Postepy Kardiol Interwencyjnej. 2023 Dec;19(4):333-342. doi: 10.5114/aic.2023.133475. Epub 2023 Dec 6.

Authors

Chunyu Zhao¹, Tianze Liu², Hong Wei³, Jianing Li¹

Affiliations

¹ Department of General Practice, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
² Clinical Medical College of Jiamusi University, Jiamusi, Heilongjiang, China.
³ Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Abstract

Introduction: Serum oxidative stress factors may be considered to be essential parameters for indicating cell oxidative damage.

Aim: We designed this study to investigate the clinical diagnostic value of serum oxidative stress factors (superoxide dismutase (SOD), malondialdehyde (MDA), and myeloperoxidase (MPO)) combined with ischemia-modified albumin (IMA) and heat shock protein 70 (HSP70) for myocardial ischemia-reperfusion injury (MIRI) after percutaneous coronary intervention (PCI) in elderly patients with acute myocardial infarction (AMI) and type 2 diabetes mellitus (T2DM).

Material and methods: From November 2020 to August 2021, 94 patients with AMI + T2DM and 86 patients with AMI were enrolled in the study; they were sub-grouped into the MIRI and non-MIRI groups following the occurrence of MIRI within 48 h after PCI. SOD, MDA, MPO, IMA, and HSP70 levels were determined. The clinical values of the combined serum oxidative stress factors, IMA, and HSP70 levels to predict MIRI events were analyzed.

Results: There was a higher probability of MIRI events in the AMI + T2DM group than the AMI group (p < 0.05). The ROC curve for the combined prediction of SOD, MDA, MPO, IMA, and HSP70 for the occurrence of MIRI events was higher in both the AMI and the AMI + T2DM groups than for predictive factors alone (all p < 0.05).

Conclusions: Combined prediction of SOD, MDA, MPO, IMA, and HSP70 has the highest diagnostic value for predicting MIRI events after PCI in AMI patients, especially in patients with AMI combined with T2DM.

Keywords: HSP70; acute myocardial infarction; clinical diagnostic values; ischemia-modified albumin; myocardial ischemia-reperfusion injury; serum oxidative stress factors; type 2 diabetes mellitus.