The FEDBD plasma's quantitative investigation of skin parameters: Skin elasticity, thickness, density, tissue oxygenation, perfusion, and edema

Parisa Charipoor; Mohammad Ali Nilforoushzadeh; Mohammadreza Khani; Maryam Nouri; Erfan Ghasemi; Mohammad Amir Amirkhani; Mohammad Eftekhari; Babak Shokri

doi:10.1016/j.heliyon.2023.e23386

The FEDBD plasma's quantitative investigation of skin parameters: Skin elasticity, thickness, density, tissue oxygenation, perfusion, and edema

Heliyon. 2023 Dec 12;10(1):e23386. doi: 10.1016/j.heliyon.2023.e23386. eCollection 2024 Jan 15.

Authors

Parisa Charipoor¹, Mohammad Ali Nilforoushzadeh^{2

3}, Mohammadreza Khani¹, Maryam Nouri^{2

3}, Erfan Ghasemi¹, Mohammad Amir Amirkhani^{2

3}, Mohammad Eftekhari¹, Babak Shokri^{1

4}

Affiliations

¹ Laser-Plasma Research Institute, Shahid Beheshti University, G.C., P.O. Box, 19839-6941, Tehran, Iran.
² Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
³ Skin Repair Research Center, Jordan Dermatology and Hair Transplantation Center, Tehran, Iran.
⁴ Physics Department of Shahid Beheshti University, G.C., P.O. Box, Tehran, 19839-6941, Iran.

Abstract

This study used the FEDBD plasma device for skin rejuvenation in animal samples. There were two groups of six male Wistar rats. Before starting the treatment, immediately after the treatment, the fourth week, and the tenth week of follow-up, biometric tests were performed, including moisture level, evaporation from the skin surface, erythema and melanin, skin elasticity and firmness with an MPA9 device and cutometer. The thickness and density of the epidermis and dermis, an essential indicator in rejuvenation, were evaluated with a skin ultrasound device. Also, the level of oxygen, perfusion, and interstitial water (edema) was checked using a Tivita tissue hyperspectral camera at a depth of 6 mm of the skin.

Keywords: Cold plasma; Density; Floating electrode dielectric barrier discharge (FEDBD); Skin rejuvenation; Thickness.