YB-1: the Jekyll and Hyde of kidney disease?

Phillip Kantharidis; Mark E Cooper

doi:10.1016/j.kint.2023.10.020

YB-1: the Jekyll and Hyde of kidney disease?

Kidney Int. 2024 Jan;105(1):18-20. doi: 10.1016/j.kint.2023.10.020.

Authors

Phillip Kantharidis¹, Mark E Cooper²

Affiliations

¹ Department of Diabetes, Monash University, Central Clinical School, Alfred Research Alliance, Melbourne, Australia.
² Department of Diabetes, Monash University, Central Clinical School, Alfred Research Alliance, Melbourne, Australia. Electronic address: mark.cooper@monash.edu.

PMID: 38182288
DOI: 10.1016/j.kint.2023.10.020

Abstract

Y-box-binding protein 1 is a well-described and important regulator of gene transcription, which is linked to various pathologic conditions, including inflammation and fibrosis of the kidney. The identification of a novel and protective crosstalk pathway between podocytes and tubular cells in the kidney with Y-box-binding protein 1 acting as a paracrine messenger sheds new light and provides novel opportunities for renoprotection.

MeSH terms

Epithelial Cells
Humans
Inflammation
Kidney
Kidney Diseases*
Y-Box-Binding Protein 1*

Substances

Y-Box-Binding Protein 1