Improving cellular diversity in human cerebellar organoids

Marilyn Steyert; Tomasz Nowakowski

doi:10.1016/j.stem.2023.12.007

Improving cellular diversity in human cerebellar organoids

Cell Stem Cell. 2024 Jan 4;31(1):3-4. doi: 10.1016/j.stem.2023.12.007.

Authors

Marilyn Steyert¹, Tomasz Nowakowski²

Affiliations

¹ Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
² Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: tomasz.nowakowski@ucsf.edu.

PMID: 38181748
DOI: 10.1016/j.stem.2023.12.007

Abstract

The developing human cerebellum has a greater diversity of progenitor types than that of the mouse, necessitating a human-based model for studying cerebellar development and disease. Atamian et al.¹ developed a 3D organoid model of cerebellar development, which recapitulates many cell types found in the developing human cerebellum, including Purkinje-neuron-like cells.

MeSH terms

Animals
Cerebellum*
Humans
Mice
Organoids*