Sesamol as a potent anticancer compound: from chemistry to cellular interactions

Ajay Kumar; Payal Bajaj; Brahmjot Singh; Kapil Paul; Pooja Sharma; Sukanya Mehra; Robin; Pardeep Kaur; Shivam Jasrotia; Parveen Kumar; Rajat; Vipourpreet Singh; Hardeep Singh Tuli

doi:10.1007/s00210-023-02919-2

Sesamol as a potent anticancer compound: from chemistry to cellular interactions

Naunyn Schmiedebergs Arch Pharmacol. 2024 Jan 5. doi: 10.1007/s00210-023-02919-2. Online ahead of print.

Authors

Ajay Kumar¹, Payal Bajaj², Brahmjot Singh³, Kapil Paul⁴, Pooja Sharma⁵, Sukanya Mehra⁶, Robin⁷, Pardeep Kaur⁸, Shivam Jasrotia⁹, Parveen Kumar¹⁰, Rajat¹¹, Vipourpreet Singh¹², Hardeep Singh Tuli¹³

Affiliations

¹ University Center for Research & Development (UCRD), Biotechnology Engineering & Food Technology, Chandigarh University, Gharuan, Mohali, 140413, Punjab, India. kumar.ajay1250@gmail.com.
² Advanced Eye Center, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
³ Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, 143005, Punjab, India.
⁴ Kanya Maha Vidyalaya, Jalandhar, 144004, Punjab, India.
⁵ Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, Punjab, India.
⁶ P.G. Department of Science, Khalsa College For Women, Amritsar, 143001, Punjab, India.
⁷ Regional Water Testing Laboratory, Department of Water Supply and Sanitation, Agilent Technologies India Pvt. Ltd., Amritsar, Punjab, India.
⁸ Post Graduate Department of Botany, Khalsa College, Amritsar, Punjab, India.
⁹ Department of Biosciences, University Institute of Biotechnology, Chandigarh University, Mohali, Punjab, 140413, India.
¹⁰ Department of Chemistry, Chandigarh University, Gharuan, Mohali, 140413, Punjab, India.
¹¹ Punjab Biotechnology Incubator (PBTI), Phase VIII, Mohali, 160071, India.
¹² Coast Mountain College, Prince Rupert, British Columbia, V8J3S8, Canada.
¹³ Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana, Ambala, 133207, India.

PMID: 38180556
DOI: 10.1007/s00210-023-02919-2

Abstract

Sesamol (SM), a well-known component isolated from sesame seeds (Sesamum indicum), used in traditional medicines in treating numerous ailments. However, numerous molecular investigations revealed the various mechanisms behind its activity, emphasizing its antiproliferative, anti-inflammatory, and apoptosis-inducing properties, preventing cancer cell spread to distant organs. In several cells derived from various malignant tissues, SM-regulated signal transduction pathways and cellular targets have been identified. This review paper comprehensively describes the anticancer properties of SM and SM-viable anticancer drugs. Additionally, the interactions of this natural substance with standard anticancer drugs are examined, and the benefits of using nanotechnology in SM applications are explored. This makes SM a prime example of how ethnopharmacological knowledge can be applied to the development of contemporary drugs.

Keywords: Anti-inflammatory; Anticancer; Antiproliferative; Apoptosis; Ethnopharmacological; Nanotechnology; Sesamol.