Genetic Testing for Successful Cancer Treatment

Desh Nidhi Singh; Sushma Daripelli; Mohamed Osman Elamin Bushara; Georgiy Georgievich Polevoy; Muthu Prasanna

doi:10.7759/cureus.49889

Genetic Testing for Successful Cancer Treatment

Cureus. 2023 Dec 4;15(12):e49889. doi: 10.7759/cureus.49889. eCollection 2023 Dec.

Authors

Desh Nidhi Singh¹, Sushma Daripelli^{2

3

4}, Mohamed Osman Elamin Bushara⁵, Georgiy Georgievich Polevoy⁶, Muthu Prasanna⁷

Affiliations

¹ Microbiology, Rama Medical College Hospital & Research Centre, Kanpur, IND.
² Anatomy, Government Medical College (GMC) Jangaon, Jangaon, IND.
³ Anatomy, Gandhi Medical College, Hyderabad, IND.
⁴ Anatomy, All India Institute of Medical Sciences, Bibinagar, Bibinagar, IND.
⁵ Health Promotion & Health Education, Umm Al-Qura University, Makkah, SAU.
⁶ Physical Education, Moscow Polytechnic University, Moscow, RUS.
⁷ Pharmaceutics and Pharmaceutical Biotechnology, Surya School of Pharmacy, Surya Group of Educational Institutions, Villupuram, IND.

Abstract

Cancer genetic testing is a revolutionary medical approach that involves the assessment of genetic markers in asymptomatic individuals to predict their future susceptibility to cancer. This paradigm shift in early detection and intervention has the potential to profoundly alter our strategies for cancer prevention and treatment. One pivotal area where genetic testing can have a significant impact is among families with a hereditary predisposition to cancer. Recent research has seen a surge in the exploration of how individuals perceive their cancer risk within the realm of cancer genetics. This proactive approach to genetic testing allows healthcare professionals to identify family members who may carry the same cancer-related genetic mutations, empowering them to make informed decisions regarding their healthcare and cancer risk management. Genetic testing for cancer-related disorders has significantly improved in accuracy and affordability, potentially revolutionizing monitoring and treatment methods. The expanding knowledge of genetic mutations associated with cancer susceptibility has driven significant progress in cancer therapy. Identifying numerous major cancer susceptibility genes has propelled predictive genetic testing, providing individuals with valuable insights into their genetic predisposition to cancer. While perceived risk plays a vital role in genetic counseling, it is equally essential to offer comprehensive information about the advantages and potential risks associated with genetic testing. Ensuring that individuals have a clear understanding of the benefits and potential drawbacks of genetic testing is imperative for making informed healthcare decisions. In our comprehensive review, researchers explored several critical aspects of genetic testing in the context of cancer, including awareness and knowledge, the communication of cancer genetic risk, genetic testing for inherited cancer syndromes, and the challenges and limitations linked to genetic testing. Through this examination, we aim to illuminate the transformative potential of genetic testing in cancer prevention and treatment.

Keywords: cancer genetic testing; cancer genetics; clinical cancer genetics; oncology; study of inherited cancer syndromes.

Publication types

Review