Pediatric cutaneous T-cell neoplasm and mimics with gamma-delta expression: Not always aggressive

Jinjun Cheng; Keri Toner; Kaiane Habeshian; Michael Cardis; Edward W Cowen; Catherine M Bollard; Birte Wistinghausen; A Yasmine Kirkorian

doi:10.1002/pbc.30837

Pediatric cutaneous T-cell neoplasm and mimics with gamma-delta expression: Not always aggressive

Pediatr Blood Cancer. 2024 Mar;71(3):e30837. doi: 10.1002/pbc.30837. Epub 2024 Jan 4.

Authors

Jinjun Cheng^{1

2

3}, Keri Toner^{2

3

4}, Kaiane Habeshian^{3

5}, Michael Cardis⁶, Edward W Cowen⁷, Catherine M Bollard^{2

3

4}, Birte Wistinghausen^{2

3

4}, A Yasmine Kirkorian^{3

5}

Affiliations

¹ Department of Pathology and Laboratory Medicine, Children's National Hospital, Washington, District of Columbia, USA.
² Center for Cancer and Immunology Research, Children's National Hospital, Washington, District of Columbia, USA.
³ George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.
⁴ Center for Cancer and Blood Disorders, Children's National Hospital, Washington, District of Columbia, USA.
⁵ Division of Dermatology, Children's National Hospital, Washington, District of Columbia, USA.
⁶ Department of Dermatology, Medstar-Georgetown University School of Medicine, Washington, District of Columbia, USA.
⁷ Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, Maryland, USA.

PMID: 38177069
DOI: 10.1002/pbc.30837

Abstract

Pediatric cutaneous T-cell lymphoma with γδ immunophenotype is extremely rare. Only a few cases of γδ T-cell neoplasm have been reported in the literature, and therefore little is known whether γδ T-cell neoplasms in children are distinct from their adult counterparts with respect to the clinicopathological presentation, behavior, and prognosis. In this study, we demonstrate three unique pediatric cutaneous T-cell neoplasm and mimics with increased γδ T cells. All cases showed an indolent clinical course.

Keywords: CTCL; MF; PCGDTCL; PLC; SPTCL.

MeSH terms

Adult
Child
Humans
Lymphoma, T-Cell, Cutaneous*
Prognosis
Skin / pathology
Skin Neoplasms* / pathology
T-Lymphocytes / pathology