PET/Computed Tomography Transformation of Oncology: Ovarian Cancers

PET Clin. 2024 Apr;19(2):207-216. doi: 10.1016/j.cpet.2023.12.007. Epub 2024 Jan 4.

Abstract

Over the last quarter of a century, fluorine-18-fluorodeoxyglucose (FDG) PET/computed tomography (CT) has revolutionized the diagnostic algorithm of ovarian cancer, impacting on the initial disease evaluation including staging and surgical planning, treatment response assessment and prognostication, to the most important role in detection of recurrent disease. The role of FDG PET/CT is expanding with the adoption of new therapeutic agents. Other non-FDG tracers have been explored with fibroblast activation protein inhibitor being promising. Novel tracers may provide the basis for future theragnostic work. This article will review the evolution and impact of PET/CT in ovarian cancer management.

Keywords: Cytoreduction; Disease staging; FDG; Ovarian cancer; PET/CT; Recurrence detection.

Publication types

  • Review

MeSH terms

  • Female
  • Fluorodeoxyglucose F18*
  • Humans
  • Neoplasm Staging
  • Ovarian Neoplasms* / pathology
  • Positron Emission Tomography Computed Tomography / methods
  • Positron-Emission Tomography / methods
  • Tomography, X-Ray Computed / methods

Substances

  • Fluorodeoxyglucose F18