Preparation and characterizations of antibacterial iodine-containing coatings on pure Ti

Qiang Li; Shuaishuai Li; Hao Sun; Mitsuo Niinomi; Takayoshi Nakano

doi:10.1016/j.jmbbm.2023.106366

Preparation and characterizations of antibacterial iodine-containing coatings on pure Ti

J Mech Behav Biomed Mater. 2024 Mar:151:106366. doi: 10.1016/j.jmbbm.2023.106366. Epub 2024 Jan 1.

Authors

Qiang Li¹, Shuaishuai Li², Hao Sun², Mitsuo Niinomi³, Takayoshi Nakano⁴

Affiliations

¹ School of Mechanical Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, PR China; Shanghai Engineering Research Center of High-Performance Medical Device Materials, Shanghai, 200093, PR China. Electronic address: jxli@tju.edu.cn.
² School of Mechanical Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, PR China.
³ School of Mechanical Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, PR China; Institute for Materials Research, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai 980-8577, Japan; Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, 2-1, Yamada-Oka, Suita, Osaka 565-0871, Japan.
⁴ Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, 2-1, Yamada-Oka, Suita, Osaka 565-0871, Japan.

PMID: 38176198
DOI: 10.1016/j.jmbbm.2023.106366

Abstract

Iodine-containing coatings were prepared on pure Ti surfaces via electrochemical deposition to enhance their antibacterial properties. The factors influencing iodine content were analyzed using an orthogonal experiment. The electrochemically deposited samples were characterized using scanning electron microscopy with energy dispersive spectroscopy and X-ray photoelectron spectroscopy, and their antibacterial properties and cytotoxicity were evaluated. The results showed that changing the deposition time is an effective way to control the iodine content. The iodine content, coating thickness, and adhesion of the samples increased with deposition time. Iodine in the coatings mainly exists in three forms, which are I₂, I₃^-, and pentavalent iodine. For samples with iodine-containing coatings, the antibacterial ratios against E. coli and S. aureus were greater than 90% and increased with increasing iodine content. Although the samples with iodine-containing coatings showed some inhibition of the proliferation of MC3T3-E1 cells, the cell viabilities were all higher than 80%, suggesting that iodine-containing coatings are biosafe.

Keywords: Antibacterial properties; Coating; Cytotoxicity; Electrochemical deposition; Povidone-iodine.

MeSH terms

Anti-Bacterial Agents / pharmacology
Coated Materials, Biocompatible* / chemistry
Coated Materials, Biocompatible* / pharmacology
Escherichia coli
Iodine* / pharmacology
Staphylococcus aureus
Surface Properties
Titanium / pharmacology

Substances

Coated Materials, Biocompatible
Iodine
Titanium
Anti-Bacterial Agents