Impact of Migraine on Daily Life: Results of the Observational survey of the Epidemiology, Treatment, and Care of Migraine (OVERCOME [Japan]) Study

Etsuko Awaki; Takao Takeshima; Yasuhiko Matsumori; Koichi Hirata; Naoki Miyazaki; Ryo Takemura; Satoshi Osaga; Yoshinori Tanizawa; Mika Komori

doi:10.1007/s40120-023-00569-3

Impact of Migraine on Daily Life: Results of the Observational survey of the Epidemiology, Treatment, and Care of Migraine (OVERCOME [Japan]) Study

Neurol Ther. 2024 Feb;13(1):165-182. doi: 10.1007/s40120-023-00569-3. Epub 2024 Jan 4.

Authors

Etsuko Awaki¹, Takao Takeshima², Yasuhiko Matsumori³, Koichi Hirata⁴, Naoki Miyazaki⁵, Ryo Takemura⁵, Satoshi Osaga⁶, Yoshinori Tanizawa⁷, Mika Komori⁶

Affiliations

¹ Department of Neurology, Saiseikai Sakaiminato General Hospital, Sakaiminato, Japan.
² Department of Neurology Headache Center, Tominaga Hospital, Osaka, Japan.
³ Sendai Headache and Neurology Clinic, Sendai, Japan.
⁴ Department of Neurology, Dokkyo Medical University, Mibu, Japan.
⁵ Biostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo, Japan.
⁶ Japan Drug Development and Medical Affairs, Eli Lilly Japan K.K., 5-1-28, Isogamidori, Chuo-ku, Kobe-shi, 651-0086, Japan.
⁷ Japan Drug Development and Medical Affairs, Eli Lilly Japan K.K., 5-1-28, Isogamidori, Chuo-ku, Kobe-shi, 651-0086, Japan. tanizawa_yoshinori@lilly.com.

Abstract

Introduction: The impacts of migraine on daily life, including daily activities and fundamental health indicators (sleep and mental health), have not been described in detail for people with migraine in Japan.

Methods: The cross-sectional ObserVational survey of the Epidemiology, tReatment, and Care Of MigrainE (OVERCOME [Japan]) study was conducted between July and September 2020. Impacts of migraine on housework, family/social/leisure activities, driving, and sleep were assessed using questions from the Migraine Disability Assessment (MIDAS), Migraine-Specific Quality-of-Life Questionnaire, and Impact of Migraine on Partners and Adolescent Children scales and questions developed for OVERCOME (Japan). The Migraine Interictal Burden Scale (MIBS-4) evaluated burden on days without headaches. Depression and anxiety were assessed with the Patient Health Questionnaire (PHQ-8) and Generalized Anxiety Disorder (GAD-7) scales, respectively. Impacts on daily life were also described across MIDAS/MIBS-4 categories.

Results: Among 17,071 respondents with migraine, 24.8% required assistance with housework at least sometimes. Migraine interfered with relationships, leisure, and social activities at least sometimes for 31.8%, 41.6%, and 18.0% of respondents, respectively. Between headache days, 26.8% of respondents worried about planning social/leisure activities at least sometimes. Among respondents living with family (N = 13,548), migraine also had impacts on participation in and enjoyment of family activities. Among respondents who drove (N = 10,921), 43.9% reported that symptoms interfered with driving at least sometimes. Migraine interfered with sleep and mood at least sometimes for 52.7% and 70.7% of respondents, respectively. PHQ-8 and GAD-7 thresholds for clinical depression and anxiety were met by 28.6% and 22.0% of respondents, respectively. Impact of migraine on daily life increased with increasing severity of MIDAS/MIBS-4 categories.

Conclusion: The burden of migraine on daily activities, sleep, and mental health is substantial for people with migraine in Japan. In clinical practice, it is important to evaluate the impact of migraine on daily life in addition to migraine symptoms.

Keywords: Automobile driving; Daily life; Family; Household work; Japan; Leisure activities; Mental health; Migraine disorders; Sleep; Social participation.

Abstract

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