Correlation study of renal function indices with diabetic peripheral neuropathy and diabetic retinopathy in T2DM patients with normal renal function

Yue-Yang Zhang; Bing-Xue Chen; Zhuang Chen; Qin Wan

doi:10.3389/fpubh.2023.1302615

Correlation study of renal function indices with diabetic peripheral neuropathy and diabetic retinopathy in T2DM patients with normal renal function

Front Public Health. 2023 Dec 15:11:1302615. doi: 10.3389/fpubh.2023.1302615. eCollection 2023.

Authors

Yue-Yang Zhang^{1

2

3

4

5

6}, Bing-Xue Chen⁶, Zhuang Chen⁷, Qin Wan^{1

2

3

4

5}

Affiliations

¹ Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
² Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, China.
³ Sichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, China.
⁴ Sichuan Clinical Research Center for Nephropathy, Luzhou, China.
⁵ Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, China.
⁶ Southwest Medical University, Luzhou, China.
⁷ Medical Laboratory Centre, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Abstract

Background: The anticipation of diabetes-related complications remains a challenge for numerous T2DM patients, as there is presently no effective method for early prediction of these complications. This study aims to investigate the association between renal function-related indicators and the occurrence of peripheral neuropathy and retinopathy in individuals diagnosed with type 2 diabetes mellitus (T2DM) who currently have normal renal function.

Methods: Patients with T2DM who met the criteria were selected from the MMC database and divided into diabetic peripheral neuropathy (DPN) and diabetic retinopathy (DR) groups, with a total of 859 and 487 patients included, respectively. Multivariate logistic regression was used to analyze the relationship between blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA), urine albumin(ALB), albumin-to-creatinine ratio (ACR), estimated glomerular filtration rate (eGFR), and diabetic peripheral neuropathy and retinopathy. Spearman correlation analysis was used to determine the correlation between these indicators and peripheral neuropathy and retinopathy in diabetes.

Results: In a total of 221 patients diagnosed with DPN, we found positive correlation between the prevalence of DPN and eGFR (18.2, 23.3, 35.7%, p < 0.05). Specifically, as BUN (T1: references; T2:OR:0.598, 95%CI: 0.403, 0.886; T3:OR:1.017, 95%CI: 0.702, 1.473; p < 0.05) and eGFR (T1: references; T2:OR:1.294, 95%CI: 0.857, 1.953; T3:OR:2.142, 95%CI: 1.425, 3.222; p < 0.05) increased, the odds ratio of DPN also increased. Conversely, with an increase in Cr(T1: references; T2:OR:0.86, 95%CI: 0.56, 1.33; T3:OR:0.57, 95%CI: 0.36, 0.91; p < 0.05), the odds ratio of DPN decreased. Furthermore, when considering sensitivity and specificity, eGFR exhibited a sensitivity of 65.2% and specificity of 54.4%, with a 95% confidence interval of 0.568-0.656.

Conclusion: In this experimental sample, we found a clear positive correlation between eGFR and DPN prevalence.

Keywords: diabetic peripheral neuropathy; diabetic retinopathy; eGFR; renal function; type 2 diabetes mellitus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Albumins
Correlation of Data
Creatinine
Diabetes Mellitus, Type 2* / complications
Diabetic Neuropathies* / complications
Diabetic Neuropathies* / diagnosis
Diabetic Neuropathies* / epidemiology
Diabetic Retinopathy* / diagnosis
Diabetic Retinopathy* / epidemiology
Humans
Kidney
Retinal Diseases* / complications
Risk Factors

Substances

Creatinine
Albumins

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The Ministry of Science and Technology of China provided funding for this study through grants 2016YFC0901200.