Risk of osteoarthritis in patients with hidradenitis suppurativa: a global federated health network analysis

Hui-Chin Chang; Chih-Lung Wu; Tsu-Man Chiu; Wen-Chieh Liao; Shuo-Yan Gau

doi:10.3389/fimmu.2023.1285560

Risk of osteoarthritis in patients with hidradenitis suppurativa: a global federated health network analysis

Front Immunol. 2023 Dec 19:14:1285560. doi: 10.3389/fimmu.2023.1285560. eCollection 2023.

Authors

Hui-Chin Chang^{1

2

3}, Chih-Lung Wu^{3

4}, Tsu-Man Chiu^{3

5

6}, Wen-Chieh Liao^#^{7

8}, Shuo-Yan Gau^#^{3

9}

Affiliations

¹ Evidence-based Medicine Center, Chung Shan Medical University Hospital, Taichung, Taiwan.
² Library, Chung Shan Medical University Hospital, Taichung, Taiwan.
³ School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
⁴ Department of Orthopedic Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan.
⁵ Department of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan.
⁶ Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
⁷ Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
⁸ Doctoral Program in Tissue Engineering and Regenerative Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
⁹ Institute of Medical Education, Chi Mei Medical Center, Tainan, Taiwan.

^# Contributed equally.

Abstract

Background: Osteoarthritis and hidradenitis suppurativa (HS) share a common inflammatory pathway. However, whether patients with HS have higher risk developing osteoarthritis remained unclear.

Methods: A retrospective cohort design was adopted in this study. Electronic medical records had been retrieved from the US collaborative network in the TriNetX research network. A propensity score matching of 1:1 was performed to match for covariates. In total, 50,931 patients with HS and the same amount of non-HS controls were identified for analyses. Hazard ratio (HR) of osteoarthritis in patient with HS was calculated.

Results: Risk of patients with HS developing osteoarthritis was 1.37-fold higher than that of non-HS controls [95% confidence interval (CI), 1.21-1.55] when followed up for 1 year. The significance remained when the follow-up periods were extended to 3 years and 5 years. When osteoarthritis was stratified on occurring sites, the HR of knee osteoarthritis was 1.19 (95% CI, 1.09-1.29) and the HR of hip osteoarthritis was 1.17 (95% CI, 1.01-1.35) in the 5-year follow-up. The 5-year risk of osteoarthritis remained significant in sensitivity models.

Conclusion: Patients with HS were of high risk of developing osteoarthritis compared with people without HS. The clinical association was recommended to be considered while approaching patients with HS.

Keywords: cohort; electronic medical records; epidemiology; hidradenitis suppurativa; osteoarthritis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hidradenitis Suppurativa* / complications
Hidradenitis Suppurativa* / epidemiology
Humans
Osteoarthritis, Knee* / epidemiology
Osteoarthritis, Knee* / etiology
Retrospective Studies

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by research grants to W-CL from the National Science and Technology Council (111-2320-B-005 -009 -MY3), Taiwan.