Neutrophil extracellular traps regulating tumorimmunity in hepatocellular carcinoma

Weixiong Zhu; Chuanlei Fan; Shi Dong; Xin Li; Haofei Chen; Wence Zhou

doi:10.3389/fimmu.2023.1253964

Neutrophil extracellular traps regulating tumorimmunity in hepatocellular carcinoma

Front Immunol. 2023 Dec 18:14:1253964. doi: 10.3389/fimmu.2023.1253964. eCollection 2023.

Authors

Weixiong Zhu^#^{1

2}, Chuanlei Fan^#³, Shi Dong^{1

2}, Xin Li^{1

3}, Haofei Chen^{1

2}, Wence Zhou^{1

2}

Affiliations

¹ The Second Clinical Medical College, Lanzhou University, Lanzhou, China.
² Department of General Surgery, The Second Hospital of Lanzhou University, Lanzhou, China.
³ The First Clinical Medical College, Lanzhou University, Lanzhou, China.

^# Contributed equally.

Abstract

As a component of the innate immune system, there is emerging evidence to suggest that neutrophils may play a critical role in the initiation and progression of hepatocellular carcinoma (HCC). Neutrophil extracellular traps (NETs) are web-like chromatin structures that protrude from the membranes during neutrophil activation. Recent research has shown that NETs, which are at the forefront of the renewed interest in neutrophil studies, are increasingly intertwined with HCC. By exploring the mechanisms of NETs in HCC, we aim to improve our understanding of the role of NETs and gain deeper insights into neutrophil biology. Therefore, this article provides a summary of key findings and discusses the emerging field of NETs in HCC.

Keywords: hepatocellular carcinoma (HCC); liver ischemia-reperfusion injury (liver I/R injury); liver transplantation; neutrophil extracellular trap (NET) formation; tumorigenesis and progression.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Hepatocellular* / pathology
Extracellular Traps*
Humans
Liver Neoplasms*
Neutrophils

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was financially supported by the following funding: (1) National Natural Science Foundation of China [grant number 82260555]; (2) Medical Innovation and Development Project of Lanzhou University [grant number lzuyxcx-2022-177]; (3) Major Science and Technology Projects of Gansu Province [grant number 22ZD6FA021-4]; (4) Science and Technology Program of Gansu Province [grant number 23JRRA0996].