Treated wastewater effluent is a major contributor to concentrations of many anthropogenic chemicals in the environment. Examining patterns of these compounds measured from different catchment areas comprising the influent to a wastewater treatment plant, across many months, may reveal patterns in compound sources and seasonality helpful to management efforts. This study considers a wastewater catchment system that was sampled at six sub-catchment sites plus the treatment plant influent and effluent at seven time points spanning nine months. Wastewater samples were analyzed with LC-QTOF-MS using positive electrospray ionization and GC-QTOF-MS using negative chemical ionization and electron ionization. MS data were screened against spectral libraries to identify micropollutants. As expected, multiple classes of chemicals were represented, including pharmaceuticals, plasticizers, personal care products, and flame retardants. Patterns in the compounds seen at different sampling sites and dates reflect the varying uses and down-the-drain routes that influence micropollutant loading in sewer systems. Patterns in examined compounds revealed little spatial variation, and greater temporal variation. For example, the greatest loads of DEET were found to occur in the summer months. Additionally, groups of compounds exhibited strong correlation with each other, which could be indicative of similar down-the-drain routes (such as a group intercorrelated chemicals that are components of cleaning products) or the influence of similar physicochemical processes within the sewer system. This study contributes to the understanding of dynamics of micropollutants in sewer systems.