Three new anti-inflammatory stilbenoids and a diphenyl ether derivative from Cajanus cajan

Liyuan Yao; Xiaobao Huang; Tingting Lin; Sheng-Xiang Qiu

doi:10.1080/14786419.2023.2297862

Three new anti-inflammatory stilbenoids and a diphenyl ether derivative from Cajanus cajan

Nat Prod Res. 2024 Jan 2:1-8. doi: 10.1080/14786419.2023.2297862. Online ahead of print.

Authors

Liyuan Yao^{1

2

3}, Xiaobao Huang^{1

4}, Tingting Lin¹, Sheng-Xiang Qiu^{1

2}

Affiliations

¹ State Key Laboratory of Plant Diversity and Specialty Crops & Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.
² South China National Botanical Garden, Guangzhou, P. R. China.
³ University of Chinese Academy of Sciences, Beijing, P. R. China.
⁴ Chemistry Department, University of Wisconsin Madison, Madison, Wisconsin, USA.

PMID: 38164765
DOI: 10.1080/14786419.2023.2297862

Abstract

Three new stilbenoids, namely two rare plant-derived phenanthrenes denominated Cajananthrenes A and B (1, 2) and one bibenzyl named Cajanbenzyl (3), together with a diphenyl ether derivative designated Cajanether (4), as well as five other known compounds (5-9) were isolated from the ethanolic extract of the leaves of Cajanus cajan. Their structures were determined through extensive spectroscopic analysis including UV, IR, NMR (1D and 2D) and HRESIMS as well. A plausible biogenesis pathway was proposed for the biosynthesis of compounds 1-3. Compounds 1 and 2 displayed moderate anti-inflammatory activity as evident from the inhibitory effect on NO production in LPS-stimulated RAW 264.7 macrophages with IC₅₀ values of 73.6 and 44.6 μM respectively.

Keywords: Cajanus cajan; Pigeon pea; Stilbenoids; anti- inflammatory activity; biosynthesis.