Advanced sensor technology is widely applied in human motion monitoring and research. However, it often encounters problems such as scratches, fractures, and aging, which affect its lifespan and reliability. To address these challenges, we draw inspiration from the inherent self-healing properties of organic biological entities in nature to endow our sensors with self-healing capability. In this work, we constructed a reversible multi-hydrogen-bonded physical crosslinking network and introduced aromatic disulfide bonds into the polyurethane backbone. This design not only achieves a very high mechanical strength of the material, but also efficient self-healing properties. At 80 °C, the tensile strength of the WPU-U2D1 material reached 28.88 MPa, with a fracture elongation of 748.64%, and a self-healing efficiency as high as 99.24%. Based on this material, we successfully prepared a flexible conductive composite film (WPU@AgNW) and applied it to flexible strain sensors. The sensor demonstrated excellent sensitivity and reliability in human motion monitoring (electrical conductivity of 2.66 S cm-1), which provides a new idea for realising the breakthrough of high-performance flexible sensors. These outstanding properties makes it have great potential for application in flexible wearable devices, human-computer interaction, bionic electronic devices and other fields.