Potential application value of pigment epithelium-derived factor in sensorineural hearing loss

Zihui Sun; Xiaoguang Li; Guangfei Li; Ying Xu; Jie Meng; Wei Meng; Shuangba He

doi:10.3389/fnins.2023.1302124

Potential application value of pigment epithelium-derived factor in sensorineural hearing loss

Front Neurosci. 2023 Dec 14:17:1302124. doi: 10.3389/fnins.2023.1302124. eCollection 2023.

Authors

Zihui Sun^#^{1

2}, Xiaoguang Li^#^{1

2}, Guangfei Li^#^{1

2}, Ying Xu^#³, Jie Meng^{1

2}, Wei Meng^{1

2}, Shuangba He^{1

2}

Affiliations

¹ Department of Otolaryngology Head and Neck Surgery, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China.
² Nanjing Tongren ENT Hospital, Nanjing, China.
³ Department of Stomatology, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China.

^# Contributed equally.

Abstract

The inner ear is a complex and precise auditory perception system responsible for receiving and converting sound signals into neural signals, enabling us to perceive and understand sound. However, the occurrence and development of inner ear diseases and auditory disorders, such as sensorineural hearing loss, remain a global problem. In recent years, there has been increasing research on the treatment of inner ear diseases and auditory regeneration. Among these treatments, pigment epithelium-derived factor (PEDF), as a multifunctional secretory protein, exhibits diverse biological activities and functions through various mechanisms, and has shown potential applications in the inner ear. This minireview comprehensively evaluates the performance of PEDF in sensorineural hearing loss in inner ear and its potential targets and therapeutic prospects.

Keywords: auditory function; pigment epithelium-derived factor (PEDF); potential; sensorineural hearing loss; signaling pathway; therapeutic prospects.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Foundation for Nanjing Tongren in-Hospital Projects and Nanjing Jiangning Technology Benefiting the People Program Project (no. 2023016S), Exploration of exosome biomarkers for secretory otitis media based on mass spectrometry identification technology.