Human ApoC3 overexpression aggravates hyperlipidemia but mitigates diet-induced coronary atherosclerotic disease in SR-BI and LDL receptor double knockout mice

Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Apr;1869(3):159449. doi: 10.1016/j.bbalip.2023.159449. Epub 2023 Dec 30.

Authors

Jiawei Liao¹, Yuhui Wang², Yao Wang³, Jinjin Zhang³, Feng Wu³, George Liu², Wei Huang⁴, Ying Zhang⁵

Affiliations

¹ Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China; Institute of Cardiovascular Sciences and State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
² Institute of Cardiovascular Sciences and State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
³ Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China.
⁴ Institute of Cardiovascular Sciences and State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China. Electronic address: huangwei@bjmu.edu.cn.
⁵ Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China. Electronic address: zy114129@sina.com.

PMID: 38163622
DOI: 10.1016/j.bbalip.2023.159449

No abstract available

Keywords: ApoC3; Atherosclerosis; Coronary atherosclerotic disease; SR-BI; Triglyceride.

MeSH terms

Animals
Atherosclerosis* / genetics
Coronary Artery Disease* / genetics
Diet
Humans
Hyperlipidemias* / genetics
Mice
Mice, Knockout