Pulmonary interstitial lymphography: A prospective trial with potential impact on stereotactic ablative radiotherapy planning for early-stage lung cancer

Ryan B Ko; Jonathan A Abelson; Dominik Fleischmann; John D Louie; Gloria L Hwang; Daniel Y Sze; Emil Schüler; Kayla N Kielar; Peter G Maxim; Quynh-Thu Le; Wendy H Hara; Maximilian Diehn; Nishita Kothary; Billy W Loo Jr

doi:10.1016/j.radonc.2023.110079

Pulmonary interstitial lymphography: A prospective trial with potential impact on stereotactic ablative radiotherapy planning for early-stage lung cancer

Radiother Oncol. 2024 Feb:191:110079. doi: 10.1016/j.radonc.2023.110079. Epub 2023 Dec 30.

Authors

Affiliations

¹ Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA; Oakland University William Beaumont School of Medicine, Auburn Hills, MI, USA. Electronic address: ryanko@oakland.edu.
² Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA; Coastal Radiation Oncology, San Luis Obispo, CA, USA. Electronic address: jonathan.abelson@21co.com.
³ Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA.
⁴ Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA; Department of Radiation Physics, Division of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.
⁵ Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA; Varian Medical Systems, Stanford, CA, USA.
⁶ Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA; Department of Radiation Oncology, University of California, Irvine, CA, USA.
⁷ Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
⁸ Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
⁹ Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: kothary@stanford.edu.
¹⁰ Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: BWLoo@stanford.edu.

PMID: 38163486
DOI: 10.1016/j.radonc.2023.110079

Abstract

This prospective feasibility trial investigated pulmonary interstitial lymphography to identify thoracic primary nodal drainage (PND). A post-hoc analysis of nodal recurrences was compared with PND for patients with early-stage lung cancer; larger studies are needed to establish correlation. Exploratory PND-inclusive stereotactic ablative radiotherapy plans were assessed for dosimetric feasibility.

Keywords: Lung cancer; Lymphography; Primary nodal drainage; Regional recurrence; Sentinel lymph node; Stereotactic ablative radiotherapy; Stereotactic body radiation therapy.

Publication types

Clinical Trial

MeSH terms

Feasibility Studies
Humans
Lung
Lung Neoplasms* / diagnostic imaging
Lung Neoplasms* / radiotherapy
Lung Neoplasms* / surgery
Lymphography
Prospective Studies
Radiosurgery*