Synthesis of Metal-Organic Framework-Based ZIF-8@ZIF-67 Nanocomposites for Antibiotic Decomposition and Antibacterial Activities

Samreen Sadiq; Iltaf Khan; Muhammad Humayun; Ping Wu; Abbas Khan; Sohail Khan; Aftab Khan; Shoaib Khan; Amal Faleh Alanazi; Mohamed Bououdina

doi:10.1021/acsomega.3c07606

Synthesis of Metal-Organic Framework-Based ZIF-8@ZIF-67 Nanocomposites for Antibiotic Decomposition and Antibacterial Activities

ACS Omega. 2023 Dec 12;8(51):49244-49258. doi: 10.1021/acsomega.3c07606. eCollection 2023 Dec 26.

Authors

Samreen Sadiq¹, Iltaf Khan², Muhammad Humayun³, Ping Wu¹, Abbas Khan^{3

4}, Sohail Khan⁵, Aftab Khan⁶, Shoaib Khan⁷, Amal Faleh Alanazi³, Mohamed Bououdina³

Affiliations

¹ School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, Jiangsu, China.
² School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212100, China.
³ Energy, Water and Environment Lab, College of Humanities and Sciences, Prince Sultan University, Riyadh 11586, Saudi Arabia.
⁴ Department of Chemistry, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan.
⁵ Department of Pharmacy, University of Swabi, Swabi 94640, Khyber Pakhtunkhwa, Pakistan.
⁶ Department of Physics, School of Science, Jiangsu University of Science and Technology, Zhenjiang 212100, Jiangsu, China.
⁷ College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin 150030, China.

Abstract

Toxic antibiotic effluents and antibiotic-resistant bacteria constitute a threat to global health. So, scientists are investigating high-performance materials for antibiotic decomposition and antibacterial activities. In this novel research work, we have successfully designed ZIF-8@ZIF-67 nanocomposites via sol-gel and solvothermal approaches. The ZIF-8@ZIF-67 nanocomposite is characterized by various techniques that exhibit superior surface area enhancement, charge separation, and high light absorption performance. Yet, ZIF-8 has high adsorption rates and active sites, while ZIF-67 has larger pore volume and efficient adsorption and reaction capabilities, demonstrating that the ZIF-8@ZIF-67 nanocomposite outperforms pristine ZIF-8 and ZIF-67. Compared with pristine ZIF-8 and ZIF-67, the most active 6ZIF-67@ZIF-8 nanocomposite showed higher decomposition efficacy for ciprofloxacin (65%), levofloxacin (54%), and ofloxacin (48%). Scavenger experiments confirmed that ^•OH, ^•O^2-, and h⁺ are the most active species for the decomposition of ciprofloxacin (CIP), levofloxacin (LF), and ofloxacin (OFX), respectively. In addition, the 6ZIF-67/ZIF-8 nanocomposite suggested its potential applications in Escherichia coli for growth inhibition zone, antibacterial activity, and decreased viability. Moreover, the stability test and decomposition pathway of CIP, LF, and OFX were also proposed. Finally, our study aims to enhance the efficiency and stability of ZIF-8@ZIF-67 nanocomposite and potentially enable its applications in antibiotic decomposition, antibacterial activities, and environmental remediation.