Abnormalities of cerebral blood flow and the regional brain function in Parkinson's disease: a systematic review and multimodal neuroimaging meta-analysis

Hao Xie; Yang Yang; Qian Sun; Ze-Yang Li; Min-Hua Ni; Zhu-Hong Chen; Si-Ning Li; Pan Dai; Yan-Yan Cui; Xin-Yu Cao; Nan Jiang; Li-Juan Du; Ying Yu; Lin-Feng Yan; Guang-Bin Cui

doi:10.3389/fneur.2023.1289934

Abnormalities of cerebral blood flow and the regional brain function in Parkinson's disease: a systematic review and multimodal neuroimaging meta-analysis

Front Neurol. 2023 Dec 7:14:1289934. doi: 10.3389/fneur.2023.1289934. eCollection 2023.

Authors

Hao Xie^#¹, Yang Yang^#¹, Qian Sun^#¹, Ze-Yang Li¹, Min-Hua Ni¹, Zhu-Hong Chen¹, Si-Ning Li^{1

2}, Pan Dai^{1

2}, Yan-Yan Cui^{1

3}, Xin-Yu Cao^{1

4}, Nan Jiang¹, Li-Juan Du¹, Ying Yu¹, Lin-Feng Yan¹, Guang-Bin Cui¹

Affiliations

¹ Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi'an, Shaanxi, China.
² Faculty of Medical Technology, Xi'an Medical University, Xi'an, Shaanxi, China.
³ Faculty of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
⁴ Faculty of Medical Technology, Medical School of Yan'an University, Yan'an, Shaanxi, China.

^# Contributed equally.

Abstract

Background: Parkinson's disease (PD) is a neurodegenerative disease with high incidence rate. Resting state functional magnetic resonance imaging (rs-fMRI), as a widely used method for studying neurodegenerative diseases, has not yet been combined with two important indicators, amplitude low-frequency fluctuation (ALFF) and cerebral blood flow (CBF), for standardized analysis of PD.

Methods: In this study, we used seed-based d-mapping and permutation of subject images (SDM-PSI) software to investigate the changes in ALFF and CBF of PD patients. After obtaining the regions of PD with changes in ALFF or CBF, we conducted a multimodal analysis to identify brain regions where ALFF and CBF changed together or could not synchronize.

Results: The final study included 31 eligible trials with 37 data sets. The main analysis results showed that the ALFF of the left striatum and left anterior thalamic projection decreased in PD patients, while the CBF of the right superior frontal gyrus decreased. However, the results of multimodal analysis suggested that there were no statistically significant brain regions. In addition, the decrease of ALFF in the left striatum and the decrease of CBF in the right superior frontal gyrus was correlated with the decrease in clinical cognitive scores.

Conclusion: PD patients had a series of spontaneous brain activity abnormalities, mainly involving brain regions related to the striatum-thalamic-cortex circuit, and related to the clinical manifestations of PD. Among them, the left striatum and right superior frontal gyrus are more closely related to cognition.

Systematic review registration: https://www.crd.york.ac.uk/ PROSPERO (CRD42023390914).

Keywords: Parkinson’s disease; cognition; coordinate-based meta-analysis; functional magnetic resonance imaging; functional neuroimaging.

Publication types

Systematic Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Key Research and Development Projects of Shaanxi (Grant number 2023-YBSF-331) and “Rapid response” research project of Air Force Military Medical University (Grant number 2023KXKT025).