Bletilla striata carbon dots with alleviating effect of DSS-induced ulcerative colitis

Jiwen Huang; Mengqing Wang; Xinjian Jiang; Yuting Liu; Yunbo Ge; Chaoyan Zhang

doi:10.1016/j.bbrc.2023.149358

Bletilla striata carbon dots with alleviating effect of DSS-induced ulcerative colitis

Biochem Biophys Res Commun. 2024 Feb 5:695:149358. doi: 10.1016/j.bbrc.2023.149358. Epub 2023 Dec 20.

Authors

Jiwen Huang¹, Mengqing Wang¹, Xinjian Jiang¹, Yuting Liu¹, Yunbo Ge¹, Chaoyan Zhang²

Affiliations

¹ College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China.
² College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China; Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai, 201306, China; Laboratory of Quality and Safety Risk Assessment for Aquatic Product on Storage and Preservation (Shanghai), Ministry of Agriculture, Shanghai, 201306, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian, Liaoning, 116034, China. Electronic address: chyzhang2021@163.com.

PMID: 38159410
DOI: 10.1016/j.bbrc.2023.149358

Abstract

Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that significantly affected quality of life for patients. In this study, carbon dots based on Bletilla striata (BS-CDs) were synthesized by hydrothermal method and characterized by optical property analysis. In addition, the study measured the potential effect of BS-CDs on colonic histopathology and inflammation in dextran sulfate sodium (DSS)-induced ulcerative colitis. The results suggested that BS-CDs significantly increased colon length, improved colonic histopathology, and reduced the levels of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) in colitis mice. Taken together, BS-CDs alleviate clinical inflammation by blocking pro-inflammatory cytokines which were expected to be a potential agent for the treatment of colitis.

Keywords: Bletilla striata; Carbon dots; Inflammatory; Ulcerative colitis.

MeSH terms

Animals
Colitis* / chemically induced
Colitis, Ulcerative* / chemically induced
Colitis, Ulcerative* / drug therapy
Colitis, Ulcerative* / pathology
Colon / pathology
Cytokines / adverse effects
Dextran Sulfate
Disease Models, Animal
Humans
Inflammation / pathology
Mice
Mice, Inbred C57BL
Quality of Life

Substances

Cytokines
Dextran Sulfate