Signaling pathways of liver regeneration: Biological mechanisms and implications

Chunyan Zhang; Caifang Sun; Yabin Zhao; Bingyu Ye; GuoYing Yu

doi:10.1016/j.isci.2023.108683

Signaling pathways of liver regeneration: Biological mechanisms and implications

iScience. 2023 Dec 7;27(1):108683. doi: 10.1016/j.isci.2023.108683. eCollection 2024 Jan 19.

Authors

Chunyan Zhang¹, Caifang Sun¹, Yabin Zhao¹, Bingyu Ye¹, GuoYing Yu¹

Affiliation

¹ State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Institute of Biomedical Science, Henan Normal University, Xinxiang, Henan, China.

Abstract

The liver possesses a unique regenerative ability to restore its original mass, in this regard, partial hepatectomy (PHx) and partial liver transplantation (PLTx) can be executed smoothly and safely, which has important implications for the treatment of liver disease. Liver regeneration (LR) can be the very complicated procedure that involves multiple cytokines and transcription factors that interact with each other to activate different signaling pathways. Activation of these pathways can drive the LR process, which can be divided into three stages, namely, the initiation, progression, and termination stages. Therefore, it is important to investigate the pathways involved in LR to elucidate the mechanism of LR. This study reviews the latest research on the key signaling pathways in the different stages of LR.

Keywords: Biological sciences; Health sciences.

Publication types

Review