Vibroacoustic therapy in the treatment of patients with COVID-19 complicated by respiratory failure: a pilot randomized controlled trial

Aidos Konkayev; Assema Bekniyazova

doi:10.3389/fmed.2023.1225384

Vibroacoustic therapy in the treatment of patients with COVID-19 complicated by respiratory failure: a pilot randomized controlled trial

Front Med (Lausanne). 2023 Dec 14:10:1225384. doi: 10.3389/fmed.2023.1225384. eCollection 2023.

Authors

Aidos Konkayev^{1

2}, Assema Bekniyazova¹

Affiliations

¹ Department of Anesthesiology and Intensive Care, Astana Medical University, Astana, Kazakhstan.
² The National Scientific Center of Traumatology and Orthopedics Named After Academician Batpenov N.D., Astana, Kazakhstan.

Abstract

Introduction: Coronavirus infection is a dangerous airborne disease that can lead to serious lung damage. Data on the effectiveness of low-frequency chest vibrations in the treatment of lung diseases are available; however, not so many of them exist. Vibroacoustic pulmonary therapy is a component of physiotherapy that improves lung perfusion and drainage without requiring active patient participation. This study aimed to increase statistical efficiency through maximizing the relevant information obtained from the clinical data. Calculating the sample size to determine the power of subsequent studies was also necessary.

Research methods: A pilot randomized parallel trial involving 60 patients was conducted. The patients were divided into two equal groups, where they received sessions of vibroacoustic pulmonary therapy using the "VibroLung" device in two modes "acute respiratory distress syndrome (ARDS)" and "Pneumonia," with identical treatment. The patients were > 18 years old with detected COVID-19 by PCR and grade 2 and 3 lung lesions detected by computer tomography (CT). Blood sampling was performed in the morning at the same time before and after the hardware massage to determine PaO₂, PaCO₂, and P/F.

Results: As a result of the test, the following data were obtained: on the first day in the group using the "ARDS" mode, PaO₂ indicators averaged 65, CI 95% [58.6-73.2] and on average 77.5, CI 95% [69.8-85.2], "before" and "after," respectively, which indicates improved oxygenation after the procedure. However, in the second group with the "Pneumonia" mode after its use, PaCO₂ was higher after the session, on average 48.7, CI 95% [40.8-56.6], whereas before that, the following indicators had, on average 43.6, CI 95% [37.2-50].

Conclusion: Thus, the data obtained yielded ambiguous results, which are the basis for further study in future randomized controlled trials. As the treatment of coronavirus infection has no etiological treatment, even small shifts in the therapy of this category of patients can be significant.

Clinical trial registration: ClinicalTrials.gov, identifier NCT05143372.

Keywords: COVID-19; physiotherapy; pilot randomized trial; respiratory insufficiency; vibroacoustic therapy.

Associated data

ClinicalTrials.gov/NCT05143372