Conjunctival Marginal Zone Lymphoma in a Patient With Neurofibromatosis Type 1: A Case Report

Cureus. 2023 Nov 27;15(11):e49491. doi: 10.7759/cureus.49491. eCollection 2023 Nov.

Abstract

We present a case of painless bulbar conjunctival mass due to B-cell non-Hodgkin lymphoma (NHL), without systemic involvement, in a 76-year-old man. Following an excision biopsy, histopathologic examination and immunohistochemistry confirmed the diagnosis, prompting a referral for hemato-oncological assessment. The patient underwent comprehensive laboratory and imaging scans, subsequently receiving combined chemo-immunotherapy that resulted in complete remission to date. This case is reported as it is crucial to recognize that a conjunctival insult might emerge in neurofibromatosis type 1 (NF1) patients.

Keywords: chemo-immunotherapy; extranodal marginal zone lymphoma; neurofibromatosis type 1; neurofibromin; non-hodgkin lymphoma.

Publication types

  • Case Reports