LncRNAs in non-small cell lung cancer: novel diagnostic and prognostic biomarkers

Jiang Fu; Li Yu; Hang Yan; Shengjie Tang; Zixu Wang; Tingting Dai; Haoyu Chen; Song Zhang; Haiyang Hu; Tao Liu; Shoujun Tang; Rong He; Haining Zhou

doi:10.3389/fmolb.2023.1297198

LncRNAs in non-small cell lung cancer: novel diagnostic and prognostic biomarkers

Front Mol Biosci. 2023 Dec 13:10:1297198. doi: 10.3389/fmolb.2023.1297198. eCollection 2023.

Authors

Jiang Fu^#^{1

2}, Li Yu^#^{1

3}, Hang Yan^#^{1

4}, Shengjie Tang¹, Zixu Wang^{1

2}, Tingting Dai^{1

4}, Haoyu Chen^{1

5}, Song Zhang^{1

5}, Haiyang Hu^{1

4}, Tao Liu¹, Shoujun Tang¹, Rong He⁶, Haining Zhou^{1

2

4

5}

Affiliations

¹ Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China.
² Institute of Surgery, Graduate School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
³ Department of Physical Examination, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China.
⁴ Institute of Surgery, Graduate School, Zunyi Medical University, Zunyi, China.
⁵ Institute of Surgery, Graduate School, North Sichuan Medical College, Nanchong, China.
⁶ Department of Respiratory and Critical Care Medicine, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China.

^# Contributed equally.

Abstract

Non-small cell lung cancer (NSCLC) is one of the main causes of cancer-related death worldwide, with a serious impact on human health and life. The identification of NSCLC at an early stage is a formidable task that frequently culminates in a belated diagnosis. LncRNA is a kind of noncoding RNA with limited protein-coding capacity, and its expression is out of balance in many cancers, especially NSCLC. A large number of studies have reported that lncRNA acts a vital role in regulating angiogenesis, invasion, metastasis, and the proliferation and apoptosis of tumor cells, affecting the occurrence and development of NSCLC. Abundant evidence demonstrates that lncRNAs may serve as potential biomarkers for NSCLC diagnosis and prognosis. In this review, we summarize the latest progress in characterizing the functional mechanism of lncRNAs involved in the development of NSCLC and further discuss the role of lncRNAs in NSCLC therapy and chemotherapy resistance. We also discuss the advantages, limitations, and challenges of using lncRNAs as diagnostic or prognostic biomarkers in the management of NSCLC.

Keywords: biomarker; diagnosis; lncRNA; lung cancer; prognosis; therapy.

Publication types

Review

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. Medical Science and Technology Project of Sichuan Provincial Health Commission: 21PJ118 and Research Project of Suining Central Hospital: 2022yz102.