Design of nanoparticle-based systems for the systemic delivery of chemotherapeutics: Alternative potential routes via sublingual and buccal administration for systemic drug delivery

Kiana Bahrami; Elaine Lee; Brinkley Morse; Olivia L Lanier; Nicholas A Peppas

doi:10.1007/s13346-023-01493-7

Design of nanoparticle-based systems for the systemic delivery of chemotherapeutics: Alternative potential routes via sublingual and buccal administration for systemic drug delivery

Drug Deliv Transl Res. 2024 May;14(5):1173-1188. doi: 10.1007/s13346-023-01493-7. Epub 2023 Dec 27.

Authors

Kiana Bahrami^{1

2

3}, Elaine Lee^{1

2

4}, Brinkley Morse^{2

5

6}, Olivia L Lanier^{1

2}, Nicholas A Peppas^{7

8

9

10

11}

Affiliations

¹ Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA.
² Institute of Biomaterials, Drug Delivery and Regenerative Medicine, University of Texas at Austin, Austin, TX, USA.
³ Department of Chemical and Biomolecular Engineering, New York University, Brooklyn, NY, USA.
⁴ School of Molecular Engineering, University of Chicago, Chicago, IL, USA.
⁵ Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
⁶ Department of Neurology, Dell Medical School, University of Texas, Austin, USA.
⁷ Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA. peppas@che.utexas.edu.
⁸ Institute of Biomaterials, Drug Delivery and Regenerative Medicine, University of Texas at Austin, Austin, TX, USA. peppas@che.utexas.edu.
⁹ Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA. peppas@che.utexas.edu.
¹⁰ Department of Surgery and Perioperative Care, Dell Medical School, University of Texas at Austin, Austin, TX, USA. peppas@che.utexas.edu.
¹¹ Department of Pediatrics, Dell Medical School, University of Texas at Austin, Austin, TX, USA. peppas@che.utexas.edu.

PMID: 38151650
DOI: 10.1007/s13346-023-01493-7

Abstract

Conventional therapeutic approaches for cancer generally involve chemo- and radiation therapies that often exhibit low efficacy and induce toxic side effects. Recent years have seen significant advancements in the use of protein biologics as a promising alternative treatment option. Nanotechnology-based systems have shown great potential in providing more specific and targeted cancer treatments, thus improving upon many of the limitations associated with current treatments. The unique properties of biomaterial carriers at the nanoscale have been proven to enhance both the performance of the incorporated therapeutic agent and tumor targeting; however, many of these systems are delivered intravenously, which can cause hazardous side effects. Buccal and sublingual delivery systems offer an alternative route for more efficient delivery of nanotechnologies and drug absorption into systemic circulation. This review concentrates on emerging buccal and sublingual nanoparticle delivery systems for chemo- and protein therapeutics, their development, efficacy, and potential areas of improvement in the field. Several factors contribute to the development of effective buccal or sublingual nanoparticle delivery systems, including targeting efficiency of the nanoparticulate carriers, drug release, and carrier biocompatibility. Furthermore, the potential utilization of buccal and sublingual multilayer films combined with nanoparticle chemotherapeutic systems is outlined as a future avenue for in vitro and in vivo research.

Keywords: Bioadhesive polymers; Buccal release; Hydrogels; Sublingual release.

Publication types

Review

MeSH terms

Administration, Buccal
Drug Delivery Systems*
Drug Liberation
Nanoparticles*