Psoriasis comorbid with atherosclerosis meets in lipid metabolism

Liuping Chen; Huiqi Chen; Sien Guo; Zhijun Chen; Haifeng Yang; Yanjiao Liu; Xiaoling Chen; Xinming Chen; Tingting Du; Xinyao Long; Jiaxiong Zhao; Mingli Guo; Tianfeng Lao; DongHui Huang; Lei Wang; Jing Chen; Chunping Liu

doi:10.3389/fphar.2023.1308965

Psoriasis comorbid with atherosclerosis meets in lipid metabolism

Front Pharmacol. 2023 Dec 11:14:1308965. doi: 10.3389/fphar.2023.1308965. eCollection 2023.

Authors

Liuping Chen^#¹, Huiqi Chen^#^{2

3}, Sien Guo^{2

3}, Zhijun Chen^{2

3}, Haifeng Yang², Yanjiao Liu², Xiaoling Chen³, Xinming Chen², Tingting Du², Xinyao Long², Jiaxiong Zhao^{2

3}, Mingli Guo³, Tianfeng Lao², DongHui Huang⁴, Lei Wang^{2

5}, Jing Chen⁶, Chunping Liu^{2

5

7

8}

Affiliations

¹ Department of Critical Care Medicine, The Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan, China.
² State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
³ Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
⁴ Affiliated Zhuhai Hospital, Southern Medical University, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, China.
⁵ Department of Cardiovascular Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China.
⁶ School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China.
⁷ State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
⁸ Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou, China.

^# Contributed equally.

Abstract

Psoriasis (PSO) is a common skin disease affecting approximately 1%-3% of the population, and the incidence rate is increasing yearly. PSO is associated with a dramatically increased risk of cardiovascular disease, the most common of which is atherosclerosis (AS). In the past, inflammation was considered to be the triggering factor of the two comorbidities, but in recent years, studies have found that lipid metabolism disorders increase the probability of atherosclerosis in patients with psoriasis. In this review, we discuss epidemiological studies, clinical treatment methods, risk factors, and lipid metabolism of psoriasis and atherosclerosis comorbidities.

Keywords: atherosclerosis; comorbidity; inflammation; lipid metabolism; psoriasis.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (82104495 and 82174161), Macao Youth Scholars Program (AM2021023), Guangdong Basic and Applied Basic Research Foundation (No. 2022A1515010395), Science and Technology Foundation of Guangzhou City (No. 202102010287), State Key Laboratory of Dampness Syndrome of Chinese Medicine Research Foundation (No. SZ2021ZZ21 and SZ2022QN02), TCM Research Fund of Guangdong Provincial Hospital of Chinese Medicine (No. YN2020MS13), 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund (Guangdong-Hong Kong-Macau Joint Lab), (No. 2020B1212030006 and MY2022KF05), Dongguan Social Development Technology Project (20211800900022 and 20231800936882), and International Program for Postgraduates, Guangzhou University of Chinese Medicine.