Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing

Siti Liyana Saud Gany; Kok-Yong Chin; Jen Kit Tan; Amilia Aminuddin; Suzana Makpol

doi:10.3389/fphar.2023.1290721

Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing

Front Pharmacol. 2023 Dec 11:14:1290721. doi: 10.3389/fphar.2023.1290721. eCollection 2023.

Authors

Siti Liyana Saud Gany¹, Kok-Yong Chin², Jen Kit Tan¹, Amilia Aminuddin³, Suzana Makpol¹

Affiliations

¹ Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
² Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
³ Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Abstract

Musculoskeletal health is paramount in an ageing population susceptible to conditions such as osteoporosis, arthritis and fractures. Age-related changes in bone, muscle, and joint function result in declining musculoskeletal health, reduced mobility, increased risk of falls, and persistent discomfort. Preserving musculoskeletal wellbeing is essential for maintaining independence and enhancing the overall quality of life for the elderly. The global burden of musculoskeletal disorders is significant, impacting 1.71 billion individuals worldwide, with age-related muscle atrophy being a well-established phenomenon. Tocotrienols, a unique type of vitamin E found in various sources, demonstrate exceptional antioxidant capabilities compared to tocopherols. This characteristic positions them as promising candidates for addressing musculoskeletal challenges, particularly in mitigating inflammation and oxidative stress underlying musculoskeletal disorders. This review paper comprehensively examines existing research into the preventive and therapeutic potential of tocotrienols in addressing age-related musculoskeletal issues. It sheds light on the promising role of tocotrienols in enhancing musculoskeletal health and overall wellbeing, emphasizing their significance within the broader context of age-related health concerns.

Keywords: TRF; ageing; arthritis; muscle ageing; musculoskeletal; osteoporosis; sarcopenia; tocotrienol.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was financially supported by Universiti Kebangsaan Malaysia, Medical Faculty Fundamental Grant FF-2022-402.