Controlled electroactive release from solid-state conductive elastomer electrodes

Christopher A R Chapman; Shanila Fernandez-Patel; Nusrat Jahan; Estelle A Cuttaz; Alexey Novikov; Josef A Goding; Rylie A Green

doi:10.1016/j.mtbio.2023.100883

Controlled electroactive release from solid-state conductive elastomer electrodes

Mater Today Bio. 2023 Nov 28:23:100883. doi: 10.1016/j.mtbio.2023.100883. eCollection 2023 Dec.

Authors

Christopher A R Chapman^{1

2}, Shanila Fernandez-Patel³, Nusrat Jahan², Estelle A Cuttaz², Alexey Novikov², Josef A Goding², Rylie A Green²

Affiliations

¹ School of Engineering and Materials Science, Queen Mary University of London, Mile End, London, E1 4NS, UK.
² Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK.
³ Tumour Immunogenomics and Immunosurveillance Laboratory, University College London Cancer Institute, London, UK.

Abstract

This work highlights the development of a conductive elastomer (CE) based electrophoretic platform that enables the transfer of charged molecules from a solid-state CE electrode directly to targeted tissues. Using an elastomer-based electrode containing poly (3,4-ethylenedioxythiophene) nanowires, controlled electrophoretic delivery of methylene blue (MB) and fluorescein (FLSC) was achieved with applied voltage. Electroactive release of positively charged MB and negatively charged FLSC achieved 33.19 ± 6.47 μg release of MB and 22.36 ± 3.05 μg release of FLSC, a 24 and 20-fold increase in comparison to inhibitory voltages over 1 h. Additionally, selective, and sequential release of the two oppositely charged molecules from a single CE device was demonstrated, showing the potential of this device to be used in multi-drug treatments.

Keywords: Conducting polymer; Conductive elastomer; Controlled release; Electrophoretic release; Targeted drug delivery.