Self-Medication with Antibiotics Among Children in China: A Cross-Sectional Study of Parents' Knowledge, Attitudes, and Practices

Wenjie Qu; Xinyu Wang; Yufei Liu; Jinfeng Mao; Mengchi Liu; Yaqin Zhong; Bella Gao; Miaomiao Zhao; Yuexia Gao

doi:10.2147/IDR.S431034

Self-Medication with Antibiotics Among Children in China: A Cross-Sectional Study of Parents' Knowledge, Attitudes, and Practices

Infect Drug Resist. 2023 Dec 18:16:7683-7694. doi: 10.2147/IDR.S431034. eCollection 2023.

Authors

Wenjie Qu^#^{1

2}, Xinyu Wang^#¹, Yufei Liu³, Jinfeng Mao², Mengchi Liu⁴, Yaqin Zhong^{1

2}, Bella Gao⁵, Miaomiao Zhao¹, Yuexia Gao^{1

2}

Affiliations

¹ Department of Health Management, School of Public Health, Nantong University, Nantong, People's Republic of China.
² Institute for Health Development, Nantong University, Nantong, People's Republic of China.
³ Faculty of Health Sciences, University of Macau, Macau, People's Republic of China.
⁴ National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
⁵ Ulink College of Suzhou Industrial Park, Suzhou, Jiangsu, People's Republic of China.

^# Contributed equally.

Abstract

Background: Self-medication with antibiotics (SMA) among children is a common practice in low-income and middle-income countries, which has accelerated antibacterial abuse.

Objective: This study aimed to estimate the prevalence and associated factors of SMA among children in China, including parents' knowledge, attitudes, and practices towards antibiotic use.

Methods: A cross-sectional study based on a structured questionnaire survey of parents was conducted in Nantong between July and September 2020. A total of 1699 respondents participated. Information on participants' demographic and family characteristics, knowledge, attitudes, and practices towards antibiotics use was collected. Hierarchical binary logistic regression was used to examine the predictors of SMA among children.

Results: Among 1699 participants, 23.31% practiced SMA to their children in the past year. Cough (59.6%) was the most common symptom leading to self-medication and penicillins (85.4%) were the most commonly used drugs. Hierarchical regression indicated that parents with higher level of antibiotic knowledge scores (OR=1.163, 95% CI: 1.067-1.268) and buying antibiotics without a prescription from pharmacy (OR=1.475, 95% CI: 1.097-1.983) were more likely to practice SMA to their children both in urban and in rural areas. Storing antibiotics at home resulted in an increased likelihood of self-medication in urban areas but not in rural areas. In addition, there was also a higher probability of non-prescribed antibiotics in children without chronic diseases (OR=1.959, 95% CI:1.072-3.578).

Conclusion: The prevalence of SMA in children is high in China. Higher knowledge scores and practices of buying and storing non-prescribed antibiotics behaviors increased parents' antibiotic self-medication in their children. Practical and effective education intervention for children's rational use of antibiotics is urgently strengthened.

Keywords: China; antibiotic; antibiotic knowledge; attitude; children; self-medication.

Grants and funding

This work was supported by National Natural Science Foundation of China [72004104]. The grant agency did not involve in the design of the study, collection, analysis and interpretation of data, and writing or revising the manuscript.